Publications by authors named "Rong Wu"
Introduction: With the continuous development of the global aging trend, the mental health of older adults has been a concern by the world. The living space of older adults is limited due to the decline of their activity function. Neighborhood environment, especially the neighborhood social environment, has become an important factor affecting the mental health of older adults.
View Article and Find Full Text PDFBackground: Diabesity, a co-occurrence of diabetes and obesity, is a growing public health concern globally. The triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance, has been associated with various metabolic disorders. This study aimed to investigate the association between TyG index and new-onset diabesity in a national longitudinal study.
View Article and Find Full Text PDFContinuous glucose monitoring (CGM) using implantable glucose sensors is a critical tool in the management of diabetes. Unfortunately, current commercial glucose sensors have limited performance and lifespans , considered to be due to sensor-induced tissue reactions (inflammation, fibrosis, and vessel regression). Previously, our laboratory utilized monocyte/macrophage (Mo/MQ) deficient and depleted mice to establish a causal relationship between Mo/MQ accumulation and inflammation in glucose sensor performance .
View Article and Find Full Text PDFPurpose: There is still insufficient evidence for predicting stroke risk in patients with mild carotid atherosclerotic stenosis. This study aimed to explore the association between carotid intraplaque neovascularization (IPN) in mild stenosis and ischemic stroke, using contrast-enhanced ultrasound (CEUS) imaging.
Methods: This retrospective observational study included 369 patients from July 2021 to March 2022.
Article Synopsis
- The study aimed to investigate the emotional behavioral problems (EBP) related to learning burnout (LB) in returned migrant middle school students, focusing on the roles of internet addiction (IA) and social support (SS) as mediators.
- Data was collected from 2020 returned migrant students in Guizhou Province, China, utilizing various scales to assess EBP, LB, IA, and SS, along with advanced statistical analysis to explore mediation effects.
- Results indicated that a significant portion of the students faced EBP, and the mediation analysis revealed that both IA and SS significantly influenced the relationship between LB and EBP, suggesting that reducing internet addiction and increasing social support could help alleviate these issues.
Article Synopsis
- This study investigates lipid metabolism in patients with Wilson's Disease (WD) to uncover risk factors for dyslipidemia, aiming to improve diagnostic and treatment approaches for unexplained lipid issues.* -
- Results show that 47.73% of Wilson's disease patients have abnormal lipid levels, significantly higher than the control group, with specific metrics indicating links between liver health and lipid profiles.* -
- The study concludes that adolescents with WD are particularly prone to lipid metabolism problems, with liver damage correlating to higher triglycerides and cholesterol, while glucose metabolism appears unaffected.*
Background: Patients with recurrent or metastatic advanced colorectal cancer (mCRC) often face the clinical dilemma as this unresectable disease is continuously progressing and endangering the patients' lives. In the current study, we explored the clinical feasibility of KH903 in combination with FOLFIRI chemotherapy as a new clinical indication for mCRC.
Methods: Patients (N = 122) were randomized 1:1 to 4mg/kg q1w KH903 or 5mg/kg q2w KH903, and both groups of patients were treated with the fixed regimen of FOLFIRI (every 2 weeks) along with the KH903 therapy.
Article Synopsis
- - Sonodynamic therapy (SDT) is an emerging treatment for tough-to-treat triple-negative breast cancer (TNBC) that generates harmful reactive oxygen species (ROS) to attack cancer cells, but its effectiveness is reduced by cancer cells' survival mechanisms, specifically mitophagy.
- - Researchers developed a novel "all-in-one" strategy that combines SDT with a method to inhibit mitophagy using a specially designed liquid Z-scheme heterojunction that links different sonosensitizers, improving ROS generation when exposed to ultrasound.
- - This innovative approach not only enhances the degradation of the therapeutic agents but also adjusts the lysosomal environment to prevent cancer cells from repairing themselves, leading to a more effective elimination of TNBC
Article Synopsis
- Interfaces in heterostructures significantly affect the operation of electronic devices, impacting elements like capacitors and transistors used for memory and logic applications.
- The study uses operando off-axis electron holography to measure trapped charges at dielectric and metal/dielectric interfaces in HfO- and AlO-based nanocapacitors under applied electric fields.
- The findings reveal a high density of trapped charges at these interfaces that influences the device's electric field distribution, establishing a linear relationship between trapped charges and the applied bias for the first time.
Article Synopsis
- The study investigates the role of AIM2 inflammasome-dependent pyroptosis and neutrophil extracellular traps (NETs) in chronic liver disease (CLD), focusing on how these mechanisms contribute to liver inflammation and fibrosis.
- It was found that elevated markers of pyroptosis and NETs correlate with disease severity, and hepatic macrophages are the primary cells undergoing pyroptosis, leading to increased collagen deposition.
- The research suggests that targeting this NET-AIM2 inflammasome pathway may offer new therapeutic options for treating liver inflammation and fibrosis.
Article Synopsis
- This study investigates the effects of Zhi Zhu Ma Ren Pill (ZZMRP) on constipation in mice induced by loperamide.
- Various research methods were utilized to evaluate the mechanisms behind ZZMRP's impact, revealing significant pathological changes in the mice due to loperamide treatment.
- The results indicate that ZZMRP effectively improves constipation symptoms by reducing endoplasmic reticulum stress and apoptosis, highlighting its potential as a treatment for constipation.
Article Synopsis
- * The study found 188 pol sequences, with common genotypes being CRF07_BC and CRF01_AE, and a network analysis showed 120 linked patients grouped into 23 clusters.
- * Factors like occupation and living in suburban areas significantly affected the likelihood of high linkage, highlighting the need for improved early detection and treatment strategies specifically for older adults in these regions.
Article Synopsis
- This study focuses on creating Bi2MoO6 nanospheres with surface oxygen vacancies (SOVs) through a specific calcination process.
- The Bi2MoO6-4 sample, calcined at 350 °C for 4 hours, demonstrated exceptional photocatalytic efficiency, degrading up to 99.16% of Rhodamine B in just 50 minutes, significantly outperforming pure Bi2MoO6.
- The enhanced photocatalytic performance is linked to the SOVs improving charge separation by altering the bandgap and facilitating electron transfer due to bond breakage in the material's structure, as confirmed by density functional theory calculations.
Article Synopsis
- Diabetes mellitus is a major factor in causing renal failure and leads to worse outcomes in diabetic patients even after receiving dialysis treatments.
- The study analyzed diabetic patients undergoing their first arteriovenous access creation, comparing those with AV fistulas to those with AV grafts to assess differences in access durability and outcomes.
- Results showed that while AV grafts allowed quicker access for hemodialysis, AV fistulas offered longer functional use, indicating that patients with diabetes may face worse clinical outcomes with grafts compared to fistulas.
Article Synopsis
- The study aimed to create a nomogram using ultrasound data to predict the aggressiveness of thyroid papillary carcinoma (PTC) by analyzing diverse radiomics features.
- A total of 471 patients were analyzed, with training and validation cohorts from different institutions, and various predictive factors such as age, nodule size, and elasticity measurements were used to develop the nomogram.
- The final nomogram showed strong predictive capabilities with AUC values exceeding 0.890 in different validation cohorts, indicating it outperformed traditional ultrasound methods and offers significant clinical utility.
Article Synopsis
- A new case of OS was identified due to an unprecedented mutation in the associated gene, presenting with significant skin issues and leading to cancer on the foot.
- This discovery highlights the broad range of symptoms related to the gene's mutations and emphasizes the importance of continuous monitoring for affected individuals.
Article Synopsis
- A study aimed to create a reliable model using conventional and contrast-enhanced ultrasound features to predict microinvasion in breast ductal carcinoma in situ (DCIS) before surgery.
- Researchers analyzed data from 163 patients with DCIS, applying logistic regression to identify key risk factors and assess the model's performance using different validation sets.
- The final predictive model, represented as a nomogram, demonstrated strong accuracy and clinical usefulness, outperforming individual ultrasound methods in forecasting microinvasion risk.
Article Synopsis
- A new antimicrobial gel combining metal-organic frameworks (MOF) and platelet-rich plasma (PRP) was developed to enhance traditional gelatin gels for improved wound healing.
- The incorporation of PRP increased the gel's flexibility by over 40%, while adding MOF particles raised its strength significantly from 13 kPa to 43 kPa.
- The PRP/MOF-loaded gel not only exhibited superior cell healing properties, completely healing scratches in 48 hours, but also showed the best wound repair capability in infected rats, achieving 100% healing effectiveness.
Article Synopsis
- Acetaminophen (APAP) overdose is a major cause of drug-induced liver injury (DILI), with notable differences in how men and women are affected, pointing to potential links with gut microbiota.
- Research indicates that higher levels of a gut microbiota compound called deguelin are present in women and female mice, which may help protect against liver damage from APAP.
- Deguelin appears to reduce liver oxidative stress in male mice by inhibiting the expression of the thyrotropin receptor in liver cells, suggesting it could be a promising target for new DILI treatments based on gut microbiota.
Article Synopsis
- - The study focused on analyzing patterns and factors influencing HIV transmission among older individuals (50+) in China, utilizing genomic and spatial epidemiological methods on a sample of 432 newly diagnosed patients.
- - A total of 382 HIV sequences were analyzed, revealing that the most prevalent strains were CRF07_BC and CRF01_AE, with a notable clustering rate of 46.1%, especially among those infected through commercial heterosexual contact (61.7%).
- - The findings indicated that older individuals (≥60 years) engaging in commercial heterosexual contact were more likely to cluster, while retirees and those with higher education were less likely; significant spatial correlations of clustering were found primarily in rural areas, indicating localized spreading patterns. *
Article Synopsis
- A hollow MoSe2/CuS type-II heterojunction was created using hollow MoSe2 nanospheres, which enhances its structural properties.
- The material demonstrates broad spectral absorption from UV-Vis to NIR, improving light utilization and facilitating photocatalysis due to its core-shell structure.
- With a RhB degradation efficiency of 96.0% achieved in 120 minutes under specific light conditions, the study highlights the potential of this semiconductor heterojunction for addressing environmental challenges.
The gap-free genome of illuminates the intricate landscape of centromeres.
Hortic Res
September 2024
Article Synopsis
- The text discusses the weeping forsythia plant, highlighting its importance in traditional medicine and horticulture, while also addressing challenges in its genomic analysis due to previous reference genome issues.
- The researchers produced a Telomere-to-Telomere (T2T) assembly of the plant's genome, revealing 14 chromosomes, 33,932 protein-coding genes, and unique characteristics of centromeric regions.
- Discoveries about the age of retrotransposons and centromere dynamics suggest that asexual reproduction could influence the plant's genetic evolution, making the T2T assembly a valuable resource for future ecological and horticultural studies.
Article Synopsis
- Mirror people, who have a unique organ arrangement, face challenges with PICC placement; using IC-ECG can help accurately guide the catheter's tip location.
- A 59-year-old patient with esophageal cancer and anomalous organ positioning (mirror-image dextrocardia and situs inversus totalis) was successfully treated without complications using real-time monitoring techniques.
- This case emphasizes the importance of measuring catheter length and highlights the need for clinicians to understand specialized PICC techniques for patients with unusual anatomical configurations.
Article Synopsis
- The expansion of a (GGGGCC)n repeat in the C9ORF72 gene is linked to frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), leading to abnormal RNA structures and dipeptide repeat proteins.
- This study shows that the (GGGGCC)n RNA affects the functioning of nuclear speckles, which are essential for RNA processing, by disturbing their dynamics and sequestering crucial proteins like SRRM2.
- The disruption of nuclear speckle integrity results in significant changes in RNA splicing and contributes to neuronal damage, identifying new mechanisms and potential targets for treatment in C9-FTD/ALS.
Article Synopsis
- Urban areas in China contribute significantly to carbon emissions, making it essential to improve their emission performance for a low-carbon future.
- A study on Guangdong's cities from 1997 to 2019 shows a loose network in carbon emission performance with key cities like Shenzhen, Guangzhou, and Zhuhai acting as central nodes, while many others are relatively isolated.
- Improving a city's centrality and economic factors can enhance carbon performance, but this might also shift emissions to surrounding areas, creating challenges due to interconnected spatial effects.