Publications by authors named "Rong Qing Mo"
Article Synopsis
- Curcumin, a compound found in turmeric, and six of its analogues were tested for their effects on human prostate cancer cells (PC-3).
- The analogues (A(2)-A(6)) showed stronger inhibition of cancer cell growth and greater stimulation of apoptosis compared to curcumin itself.
- The study found a link between the analogues' ability to inhibit NF-κB activity and their effectiveness in hindering cancer growth and promoting cell death, suggesting potential for further animal testing with these compounds.
Antioxidation and tyrosinase inhibition of polyphenolic curcumin analogs.
Biosci Biotechnol Biochem
April 2012
A series of polyphenolic curcumin analogs were synthesized and their inhibitory effects on mushroom tyrosinase and the inhibition of 1,1-diphenyl-2-picryl-hydrazyl (DPPH) free radical formation were evaluated. The results indictated that the analogs possessing m-diphenols and o-diphenols exhibited more potent inhibitory activity on tyrosinase than reference compound rojic acid, and that the analogs with o-diphenols exhibited more potent inhibitory activity of DPPH free-radical formation than reference compound vitamin C. The inhibition kinetics, analyzed by Lineweaver-Burk plots, revealed that compounds B(2) and C(2) bearing o-diphenols were non-competitive inhibitors, while compounds B(11) and C(11) bearing m-diphenols were competitive inhibitors.
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