The Glycosyltransferase XYLT1 Activates NF-κB Signaling to Promote Metastasis of Early-Stage Lung Adenocarcinoma.

Early-stage lung adenocarcinoma (LUAD) generally has a favorable prognosis. However, more than 30% of early-stage LUAD cases relapse within 5 years of initial treatment, even following complete removal of the primary tumor. Identification of the factors contributing to early-stage LUAD metastasis is needed to develop effective prevention and treatment strategies.

Upregulation of WDR4 mediated by RBFOX2 promotes laryngeal cancer progression through the WDR4/m7G/lncRNA ZFAS1/RBFOX2 axis.

High levels of the N7 methylguanosine (m7G) methyltransferase WD repeat domain 4 (WDR4) are associated with the progression of multiple tumors, including head and neck squamous cell carcinoma. Laryngeal cancer (LC) is the second most common malignant tumor of the head and neck. However, the role of WDR4 in LC remains unclear.

The Effect of Loneliness on Work Engagement among Chinese Seafarers: Mediating Effects of Executive Functions.

In order to explore the effect of loneliness on work engagement and the role of executive function in Chinese seafarers, two studies were carried out. Study 1 conducted a questionnaire survey of 1231 active Chinese seafarers to examine the relationship between seafarers' loneliness, work engagement, and executive functions. Study 2 involved 177 seafarers as participants and created scenarios of seafarer work loneliness and non-loneliness using a recall paradigm, measuring components of executive function such as inhibitory control, working memory, and cognitive flexibility, as well as willingness to engage in work.

The relationship between college students' belief in a just world and online prosocial behavior.

Previous studies have highlighted the critical role that the belief in a just world (BJW) plays in maintaining and promoting prosocial behaviors within individuals. Considered a stable personality trait, the crux of BJW lies in the conviction that individuals receive what they deserve, and deserve what they receive. Simultaneously, the relationship between BJW and prosocial behavior is impacted by an individual's sense of fairness or unfairness.

Integrative learning in the lens of meta-learned models of cognition: Impacts on animal and human learning outcomes.

This commentary examines the synergy between meta-learned models of cognition and integrative learning in enhancing animal and human learning outcomes. It highlights three integrative learning modes - holistic integration of parts, top-down reasoning, and generalization with in-depth analysis - and their alignment with meta-learned models of cognition. This convergence promises significant advances in educational practices, artificial intelligence, and cognitive neuroscience, offering a novel perspective on learning and cognition.

Kidney Outcomes Following Angiotensin Receptor-Neprilysin Inhibitor vs Angiotensin-Converting Enzyme Inhibitor/Angiotensin Receptor Blocker Therapy for Thrombotic Microangiopathy.

Importance: Thrombotic microangiopathy (TMA) on kidney biopsy is a pattern of endothelial injury commonly seen in malignant hypertension (mHTN), but treatment strategies are not well established.

Objective: To evaluate the kidney outcomes of angiotensin receptor-neprilysin inhibitor (ARNI), specifically sacubitril/valsartan, vs angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) therapy for patients with mHTN-associated TMA.

Design, Setting, And Participants: This single-center cohort study enrolled consecutive patients in China diagnosed with mHTN-associated TMA through kidney biopsy from January 2008 to June 2023.

The impact of reading metacognitive strategies on mathematics learning efficiency and performance: An analysis using PISA 2018 data in China.

The current study employed latent profile analysis to examine the application patterns of students' reading metacognitive strategies using PISA 2018 data in China. Subsequently, it explored the differences in students' mathematics learning efficiency and performance. The results revealed that: (1) Six types of reading metacognitive strategies application patterns were identified: "Novice - indifferent," "Veteran - average," "Novice - low evaluating," "Veteran - skilled," "Novice - mixed," and "Novice - arbitrary.

The effect of social media upward comparison on Chinese adolescent learning engagement: a moderated multiple mediation model.

To investigate the mechanisms and boundary conditions of social media upward comparison on adolescents' learning engagement, this study utilized two separate approaches. In research 1, a convenience sampling method was employed to conduct a questionnaire survey among 609 adolescents. The aim was to explore the influence of social media's upward comparative tendency on learning engagement.

Does China's residential mobility reduce fertility intentions? The mediating role of well-being.

With declining fertility rates becoming a global trend, it is crucial to enhance the fertility intentions of mobile individuals of reproductive age. This study utilizes both questionnaire surveys and experimental methods to examine the influence of residential mobility on fertility intentions and the mediating role of well-being. The consistent findings from Study 1 and Study 2 (2a and 2b) indicate that residential mobility significantly negatively predicts individuals' fertility intentions, and well-being plays a significant mediating role between residential mobility and fertility intentions.

Genomic characterisation of de novo EGFR copy number gain and its impact on the efficacy of first-line EGFR-tyrosine kinase inhibitors for EGFR mutated non-small cell lung cancer.

Background: Non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutation generally respond well to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs). However, genomic characterisation of de novo EGFR copy number gain (CNG) and its impact on the efficacy of first-line EGFR-TKIs remains unclear.

Methods: This multicenter, retrospective and real-world study included two cohorts that enroled EGFR mutant NSCLC patients.

PHF14 enhances DNA methylation of SMAD7 gene to promote TGF-β-driven lung adenocarcinoma metastasis.

Aberrant activation of TGF-β signaling plays a pivotal role in cancer metastasis and progression. However, molecular mechanisms underlying the dysregulation of TGF-β pathway remain to be understood. Here, we found that SMAD7, a direct downstream transcriptional target and also a key antagonist of TGF-β signaling, is transcriptionally suppressed in lung adenocarcinoma (LAD) due to DNA hypermethylation.

"Integrative learning" promotes learning but not memory in older rats.

Background: We had previously advanced the concept of "Integrative Learning", that is, "under the role of 'meta-learning self', learners actively integrate learning materials to achieve rapid and in-depth understanding of knowledge", and designed an animal behavioral model to compare the effects of "Integrative Learning" (IL) . "Progressive Learning" (PL) in young rats. It was found that IL is more advantageous than PL.

LncRNA ZFAS1 promotes laryngeal cancer progression through RBFOX2-mediated MENA alternative splicing.

Laryngeal cancer (LC) is the most common aggressive malignancy of the head and neck. LncRNA ZNFX1 antisense RNA 1 (ZFAS1) displays oncogenic properties in head and neck squamous cell carcinoma, but its regulatory role in laryngeal cancer progression remains obscure. Here, we found that ZFAS1 expression in laryngeal cancer tissues and cells was higher than that in adjacent normal tissues and normal nasopharyngeal epithelial cells.

The relationship between social class and subjective well-being: A serial mediation model.

Despite recent research associating social class with subjective well-being (SWB), the relationship between the two, manifested through victim justice sensitivity and envy, has not been properly investigated. Guided by social comparison and social cognitive tendency theories, we explored the direct and indirect relationships between social class and SWB among Chinese undergraduate students. This study employed a cross-sectional, questionnaire-based research design.

The relationship between cyberbullying victimization and cyberbullying perpetration: The role of social responsibility.

Previous studies have found some influencing factors of cyberbullying. However, little is known about how cyberbullying victimization and social responsibility influence college students' cyberbullying perpetration or about the mediating and moderating mechanisms underlying these relationships. Social responsibility involves not only individuals' deep cognition and special emotional identification of social responsibility but also their firm attitude and responsible actions.

Does a Healthy Lifestyle Lower the Elevated Risk of Obesity Caused by Caesarian Section Delivery in Children and Adolescents?

Background: Both caesarean section (CS) and lifestyle were linked with child adiposity. This study aimed to investigate whether CS delivery is linked with elevated risk of child adiposity regardless of a healthy lifestyle. Methods: All the subjects in this study came from a baseline survey of a national school-based program on healthy lifestyle interventions against adiposity among Chinese children and adolescents.

Empathy and teachers' fairness behavior: The mediating role of moral obligation and moderating role of social value orientation.

This study examined the mediating effect of moral obligation and moderating effect of social value orientation on the relationship between empathy and fairness behavior in Chinese teachers. Seven hundred and twenty-six Chinese teachers completed self-reported questionnaires regarding empathy, moral obligation, social value orientation, and fairness behavior. The results revealed that moral obligation mediated the link between empathy and teachers' fairness behavior.

Metastatic Tumor Cell-Specific FABP7 Promotes NSCLC Metastasis via Inhibiting β-Catenin Degradation.

Metastasis accounts for 90% of cancer-related deaths and represents a prominent malignant feature in non-small cell lung cancer (NSCLC), while tumor cell-specific mechanisms and molecules pivotal for the metastatic capacity remain unclear. By analyzing single-cell RNA sequencing data, we found that fatty acid binding protein 7 (FABP7) was specifically up-regulated in tumor cells of metastatic NSCLC patients and might be a prognostic indicator for poor survival. Experimental studies based on NSCLC cell lines showed that FABP7 promoted the metastatic competencies of NSCLC cells in vitro and in vivo.

Depleting hsa_circ_0000567 suppresses acquired gefitinib resistance and proliferation of lung adenocarcinoma cells through regulating the miR-377-3p / ZFX axis: an in vitro and in vivo study.

Background: Circular RNAs (circRNAs) expression profile has been reported in lung adenocarcinoma (LUAD) cells resistant to gefitinib, and hsa_circ_0000567 was abnormally upregulated. However, its precise role in gefitinib resistance remains unclarified.

Methods: Levels of hsa_circ_0000567, microRNA (miR)-377-3p and zinc finger protein X-linked (ZFX) were detected by real-time quantitative PCR.

Social Support and a Sense of Purpose: The Role of Personal Growth Initiative and Academic Self-Efficacy.

Studies have consistently found a positive relationship between social support and a sense of purpose; however, less is known about the underlying mechanisms of this relationship. The present study bridges this gap by proposing and testing a path model illustrating the mediating effects of personal growth initiative and academic self-efficacy on the linkage between social support and a sense of purpose. A total of 2,085 Chinese college students completed the revised versions of the Social Support, Personal Growth Initiative, Academic Self-Efficacy, and Sense of Purpose Scales.

Dispositional Awe and Online Altruism: Testing a Moderated Mediating Model.

Dispositional awe has a positive effect on prosociality. However, it has not been tested whether this disposition appears in online altruism. Using a large sample of 3,080 Chinese undergraduates, this study tested a moderated mediating model that takes self-transcendent meaning in life (STML) as a mediator and subjective socioeconomic status (SSES) as a moderator.

Openness to experience and dispositional awe: The moderating role of subjective socioeconomic status and mediating role of Zhong-Yong thinking style in Chinese undergraduates.

Existing research has established that openness to experience can enhance dispositional awe. For the first time, the current study examines whether subjective socioeconomic status (SSES) moderates and a Zhong-Yong thinking style mediates this effect. A sample of 2,377 Chinese undergraduates (mean age 20.

AKT-induced lncRNA VAL promotes EMT-independent metastasis through diminishing Trim16-dependent Vimentin degradation.

Despite the importance of AKT overactivation in tumor progression, results from clinical trials of various AKT inhibitors remain suboptimal, suggesting that AKT-driven tumor metastasis needs to be further understood. Herein, based on long non-coding RNA (lncRNA) profiling induced by active AKT, we identify that VAL (Vimentin associated lncRNA, LINC01546), which is directly induced by AKT/STAT3 signaling, functions as a potent pro-metastatic molecule and is essential for active AKT-induced tumor invasion, metastasis and anoikis resistance in lung adenocarcinoma (LAD). Impressively, chemosynthetic siRNAs against VAL shows great therapeutic potential in AKT overactivation-driven metastasis.

Effects of nitrogen source and N/P on growth and photosynthesis in the invasive marine macroalga Chaetomorpha valida.

The invasive marine macroalga Chaetomorpha valida blooms frequently in Apostichopus japonicus culture ponds in North China, resulting in negative environmental consequences. The factors driving this algal overgrowth are unclear. Previous studies observed that eutrophication strongly influences abnormal growth of nuisance macrophytes, but relatively few studies have addressed the types and abundance of nitrogen in A.