Clinical value of systemic immunoinflammatory index in predicting recurrence and metastasis in patients with primary liver cancer.

Background: Primary liver cancer is a highly aggressive neoplasm with high incidence and mortality. Due to the high ability to metastasis, the 5-year survival rate of patients with primary liver cancer is poor.

Aim: To investigate the clinical value of systemic immunoinflammatory index (SII) in predicting recurrence and metastasis after interventional therapy in patients with primary liver cancer.

Psychometric testing of Chinese version of screening tools (PASS) and GAD among perinatal population: hospital based evidence 2023.

Background: Anxiety disorders are increasing worldwide, untreated anxiety is linked to maternal and child health outcomes. The purpose of this study is to test psychometric properties of the Perinatal Anxiety Screening Scale (PASS) among Chinese women.

Methods: The PASS was translated into Chinese following Beaton's intercultural debugging guide.

Endogenous ERMAP Affects T-Cell Function in EAE Mice.

Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune disease (AID) mediated by myelin-reactive CD4 T cells. Experimental autoimmune encephalomyelitis (EAE) is a widely used animal model of human MS. Erythrocyte membrane-associated protein (ERMAP) is a novel erythrocyte-specific adhesion/receptor molecule associated with erythrocyte adhesion.

AIE and ICT Synergistic Lysosome-Targeted Ratiometric Fluorescence Sensor for the Detection and Imaging of Th in the Liver of Zebrafish and Mice.

The sensitive detection of the radioactive thorium (Th) ion with an oxidation state of +4 (Th) is of great significance for environmental protection and life safety. In this study, five fluorescence sensors with regulated donor-acceptor (D-A) interactions were constructed for Th detection based on intramolecular charge transfer and aggregation-induced emission mechanisms. Among the developed sensors, bearing electron-deficient π-bridge and weak D-A interactions presented ratiometric fluorescence detection behavior toward Th in aqueous solution due to its aggregation-induced emission characteristics and unique D-A-D structures.

Impact of sodium butyrate on stroke-related intestinal injury in diabetic mice: interference with Caspase-1/GSDMD pyroptosis pathway and preservation of intestinal barrier.

Diabetic stroke-associated acute intestinal injury is characterized by high mortality, disability, and poor prognosis due to the lack of effective therapies. Our prior research demonstrated that administration of 300 mg/kg sodium butyrate (NaB) can improve neurological outcomes post-diabetic stroke. Nonetheless, whether the effect of NaB is related to intestinal regulation, along with its underlying mechanisms, remains uncertain.

Automated deep learning-assisted early detection of radiation-induced temporal lobe injury on MRI: a multicenter retrospective analysis.

Objectives: To evaluate the benefits of an automated deep learning-based tool (RTLI-DM) for early detection of radiation-induced temporal lobe injury (RTLI) on MRI.

Materials And Methods: A total of 396 RTLI and 3181 non-RTLI patients were retrospectively included from a cohort of 6483 NPC patients who underwent radiotherapy and MRI follow-ups at four hospitals from January 2010 to June 2021. We developed and validated an automated RTLI-DM using the initial abnormal MRI of RTLI patients and the final MRI of non-RTLI patients.

Charge photogeneration dynamics in random terpolymer donor-based non-fullerene polymer solar cells.

Random ternary polymerization is a strategy for tuning the energy levels and improving the batch-to-batch reproducibility of polymer semiconductors for the application in polymer solar cells (PSCs). However, the influence of third component incorporation on exciton properties and charge photogeneration processes in terpolymer-based solar cells is still unclear. In this work, time-resolved spectroscopies were employed to study exciton properties and charge photogeneration processes in PSCs based on a series of terpolymers, PM1 and PM2, which have 20% and 50% of thiophene-thiazolothiazole (TTz) building blocks on the PM6 backbone, respectively.

Integrated microfluidics-based construction of anti-BTN2A2 gel droplet cell preparations for non-invasive tumor-infiltrating lymphocyte therapy.

Tumor infiltrating lymphocyte therapy (TIL therapy) is one of the effective treatments for solid tumors. However, certain periods or sites of solid tumors are not amenable to surgical resection. Meanwhile, the abundant and dense extracellular matrix (ECM) and regulatory cells (e.

Development and evaluation of USCnet: an AI-based model for preoperative prediction of infectious and non-infectious urolithiasis.

Background: Urolithiasis, a prevalent condition characterized by a high rate of incidence and recurrence, necessitates accurate preoperative diagnostic methods to determine stone composition for effective clinical management. Current diagnostic practices, reliant on postoperative specimen analysis, often fail to facilitate timely and precise therapeutic decisions, leading to suboptimal clinical outcomes. This study introduces an artificial intelligence model developed to predict infectious and non-infectious urolithiasis preoperatively using clinical data and CT imaging.

Structural basis of ssDNA-guided NADase activation of prokaryotic SPARTA system.

Short prokaryotic Argonaute and the associated TIR-APAZ (SPARTA) proteins constitute a prokaryotic immune system, mediating RNA- or DNA-guided target single-stranded DNA (ssDNA) to activate NADase activity and induce cell death by degrading NAD+ in response to invading plasmids. Although the guide RNA-mediated targeting mechanism of SPARTA has been established, the functional role and mechanisms of guide DNA-mediated SPARTA remain poorly understood. Here, we report two crystal structures of Crenotalea thermophila SPARTA complexes with 5'-phosphorylated 21-nt guide DNA and complementary target ssDNA lengths of 15 or 20 nt.

Combining pelvic floor ultrasonography with deep learning to diagnose anterior compartment organ prolapse.

Background: Anterior compartment prolapse is a common pelvic organ prolapse (POP), which occurs frequently among middle-aged and elderly women and can cause urinary incontinence, perineal pain and swelling, and seriously affect their physical and mental health. At present, pelvic floor ultrasound is the primary examination method, but it is not carried out by many primary medical institutions due to the significant shortcomings of training in the early stage and the variable image quality. There has been great progress in the application of deep learning (DL) in image-based diagnosis in various clinical contexts.

Progress on direct regulation of systemic immunity by the central nervous system.

This article reviews the research progress on the direct regulation of the immune system by the central nervous system. The traditional "neuro-endocrine-immune" network model has confirmed the close connection between the central nervous system and the immune system. However, due to the complex mediating role of the endocrine system, its application in clinical treatment is limited.

Changes in physical fitness in acute leukemia patients during chemotherapy.

This study aimed to investigate the changes in physical fitness and patient-reported outcomes as well as the correlation between these two factors in adult patients with newly diagnosed acute leukemia during chemotherapy. This was a longitudinal observational study. Patients were recruited from a tertiary hospital in China with a follow-up period of less than 90 days.

Finely Tailoring Metal-Support Interactions via Transient High-Temperature Pulses.

Metal-support interactions (MSI) play a crucial role in enhancing the catalytic activity and stability of metal catalysts by establishing a stable metal-oxide interface. However, precisely controlling MSI at the atomic scale remains a significant challenge, as how to construct an optimal MSI is still not fully understood: Both insufficient and excessive MSI showed inferior catalytic performance. In this study, we propose finely tuning MSI using temporal-precise transient high-temperature pulse heating.

Recent Advances in Reactive Oxygen Species -Mediated Near-Infrared Organic Long-Persistent Luminescence Imaging.

Organic luminophores have found extensive applications in cellular and in vivo fluorescence imaging. However, their efficacy is often hindered by formidable challenges, including a low signal-to-noise ratio (SNR), susceptibility to false-positive signals, limited tissue penetration depth, and autofluorescence arising from non-negligible background interference. The emergence of near-infrared (NIR) afterglow imaging has addressed these problems.

Exploring experiences and needs among children with cancer undergoing peripherally inserted central catheter insertion: A qualitative study.

Objective: This study aimed to explore the experiences of children with cancer undergoing peripherally inserted central catheter (PICC) insertion.

Methods: This study employed a descriptive qualitative approach. A total of 20 children undergoing PICC insertion were enrolled through purposive sampling.

Glaucoma animal models in rabbits: State of the art and perspectives-A review.

Glaucoma, a visual thief, is characterized by elevated intraocular pressure (IOP) and the loss of retinal ganglion cells (RGCs). Selecting suitable animals for preclinical models is of great significance in research on the prevention, early screening, and effective treatments of glaucoma. Rabbit eyeballs possess similar vascularity and aqueous humor outflow pathways to those of humans.

Comparative study on charge photogeneration dynamics of Y small molecule and polymerized Y small molecule based polymer solar cells.

Understanding charge photogeneration processes in polymer solar cells utilizing polymerized Y-molecule acceptors (PYMAs) is of great importance for design and optimization of high-performance solar cells. In this work, excited state dynamics in PYMAs (PYT, PY-DT) and corresponding solar cells were comparably studied with those of Y small molecules (Y5, Y6) by using the steady state and time-resolved spectroscopies as well as time-dependent density functional theory calculation. We find that PYMA (PYT, PY-DT) films exhibit smaller Stokes shifts than that of Y small molecules, indicating a more rigid backbone of PYMAs.

Combination of extrusion and bamboo leaf flavonoids modulates in vitro maize starch digestion: Insight into the molecular mechanisms and multi-scale structure.

This study investigates the combined effects of extrusion processing and bamboo leaf flavonoids (BLFs) on the digestive properties and multiscale structure of maize starch (MS). Extrusion increased the levels of rapidly digestible starch (RDS) and slowly digestible starch while the content of resistant starch (RS) decreased to 20.19 %.

A chromosome-level genome assembly of the cabbage aphid Brevicoryne brassicae.

The cabbage aphid, Brevicoryne brassicae, is a major pest on Brassicaceae plants, causing significant yield losses annually. However, the lack of genomic resources has hindered progress in understanding this pest at the molecular level. Here, we present a high-quality, chromosomal-level genome assembly for B.

Kirkendall Effect-Mediated Transformation of ZIF-67 to NiCo-LDH Nanocages as Oxidase Mimics for Multicolor Point-of-Care Testing of β-Galactosidase Activity and .

Early and portable detection of pathogenic bacteria is crucial for ensuring food safety, monitoring product quality, and tracing the sources of bacterial infections. Moving beyond traditional plate-culture counting methods, the analysis of active bacterial components offers a rapid means of quantifying bacteria. Here, metal-organic framework (MOF)-derived NiCo-layered double hydroxide nanosheets (LDHs), synthesized via the Kirkendall effect, were employed as highly effective oxidase mimics to generate reactive oxygen species (ROS).

A genomic variation map provides insights into potato evolution and key agronomic traits.

Hybrid potato breeding based on diploid inbred lines is transforming the way of genetic improvement of this staple food crop, which requires a deep understanding of potato domestication and differentiation. In the present study, we resequenced 314 diploid wild and landrace accessions to generate a variome map of 47,203,407 variants. Using the variome map, we discovered the reshaping of tuber transcriptome during potato domestication, characterized genome-wide differentiation between landrace groups Stenotomum and Phureja.

Burden of Intracerebral Hemorrhage in Asia from 1990 to 2030: A Population-Based Study.

Background: Intracerebral hemorrhage represents a critical subtype of stroke, imposing substantial social and economic challenges. Considering the considerable impact of intracerebral hemorrhage in Asia and the absence of studies detailing its epidemiological features, the aim of this study was to elucidate the temporal trends and distribution characteristics of intracerebral hemorrhage in Asia from 1990 to 2021, as well as to forecast the future burden.

Methods: The data derived from Global Disease Burden Study 2021 were used to investigate the age-standardized rates and absolute numbers of incident intracerebral hemorrhage cases and related deaths in Asia across genders, age groups, and geographical locations.

The association between the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio and delirium in ischemic stroke patients.

Background: Delirium is a severe neuropsychiatric symptom following acute ischemic stroke (IS) and is associated with poor outcomes. Systemic inflammation and immune dysregulation are believed to contribute to the pathophysiology of delirium. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) are widely recognized as convenient and reliable biomarkers of systemic inflammation.

Evidence summary of lifestyle interventions in adults with metabolic dysfunction-associated steatotic liver disease.

Objective: In this study, our objective was to provide practice recommendations by thoroughly examining lifestyle interventions for adults diagnosed with metabolic dysfunction-associated steatotic liver disease (MASLD). This was achieved through a systematic review of the literature, specifically focusing on lifestyle modification interventions in adults with MASLD.

Methods: The PIPOST (Population, Intervention, Professional, Outcome, Setting, and Type of evidence) framework was used to identify the questions for summarizing evidence.