Medium-Chain Chlorinated Paraffins Induced Reproductive Toxicity in Female Rats by Interfering with Oocyte Meiosis and Triggering DNA Damage.

Medium-chain chlorinated paraffins (MCCPs) are among the most prevalent chemicals detected in human serum. As an emerging persistent organic pollutant, their toxicity mechanisms, particularly concerning the female reproductive system, remain poorly understood. In this study, we present both and evidence of ovarian toxicity induced by MCCPs and insights into their underlying molecular mechanisms.

Storage Stability and Lipidomic Analysis Reveal the Effect of Frozen Storage Temperature on Pacific Saury ().

Objectives: This study aimed to assess the effects of storage temperature on the lipidomics profile change in Pacific saury ().

Methods: In this paper, underwent frozen storage at two different temperatures, T1 (-18 °C) and T2 (-25 °C), for a duration of three months. Chemical and lipidomic methods were used to determine the changes in lipids during the storage process.

Observation of metal-organic interphase in Cu-based electrochemical CO-to-ethanol conversion.

Interphases are critical in electrochemical systems, influencing performance by controlling ion transport and stability. This study explores a metal-organic interphase in the electrocatalytic reduction of CO (CORR) on Cu, extending the concept of interphases to CO conversion. Investigating organic modifications on CuO, we discover metal-organic interphases over 10 nm thick in highly ethanol-selective systems, contrary to the expected monolayer adsorption.

Smart bacteria cellulose facial mask for sensing and recovering skin pH.

The utilization of skin care products and cleansers is a prevalent method for maintaining facial skin health. However, excessive use of these products is an unnoticed factor that can result in serious skin problems. Currently, there are no products on the market to provide users with skin acclimatization and restoration services.

Population Pharmacokinetic of Epidural Sufentanil in Labouring Women: A Multicentric, Prospective, Observational Study.

Purpose: The effects of sufentanil-ropivacaine combination on the parturient women and the course of labor have been well documented. However, there is little information regarding the time-dependent pharmacokinetic characteristics of sufentanil after epidural administration in laboring women. We aimed to develop a population PK model for epidural sufentanil in laboring women to evaluate the sufentanil placental transfer quantitatively.

Steering CO electroreduction to hydrocarbons over 2D thiol-based conductive metal-organic framework.

Almost all of CuS compounds only produce the simple two-electron transferred products CO and HCOOH but it remains a large challenge to obtain the multiple-electron transferred hydrocarbon products in electrocatalytic CO reduction reaction (CORR). Moreover, identifying the distinct contributions of S atoms to catalysis, particularly for catalytic activity and product selectivity in electrocatalytic CORR, remains a challenging task. Herein, we introduce a model catalyst based on a conductive two-dimensional metal-organic framework with defined Cu-S active sites, named Cu(THT) (THT = 2,3,6,7,10,11-hexathiotriphenylene) for CORR.

Clinical analysis of different intestinal reconstruction methods after primary cytoreductive surgery combined with rectal resection for advanced ovarian cancer.

Objective: To compare different intestinal reconstruction methods after intestinal resection for advanced ovarian malignancy.

Methods: Retrospective data of patients with advanced ovarian malignancy were collected and then assigned into three groups: primary intestinal anastomosis, protective enterostomy and colostomy. General clinical characteristics, intraoperative findings and postoperative outcomes were compared between the three groups.

A Nationwide Investigation of Substituted -Phenylenediamines (PPDs) and PPD-Quinones in the Riverine Waters of China.

-(1,3-Dimethylbutyl)-'-phenyl--phenylenediamine-quinone (6PPD-Q) has been identified as the cause of the "urban runoff mortality syndrome." Thus, the ecological risks of substituted -phenylenediamines (PPDs) and their quinone derivatives (PPD-Qs) in water have gained global attention. However, large-scale observation of their pollution characteristics in surface water is still lacking.

Green biosynthetic silver nanoparticles from as multifunctional hemostatic agents: Combining hemostasis, antibacterial, and anti-inflammatory properties for effective wound healing.

Widespread interest in new hemostatic agents arises from the challenge of simultaneously satisfying the requirements of hemostatic, antibacterial, and anti-inflammatory properties while also considering the associated economic costs. An ideal hemostasis material should facilitate rapid hemostasis, intervene against infection, promote wound healing, and be cost-effective and easy to prepare. Herein, we demonstrate that medicinal plant-derived silver nanoparticles (AgNPs) exhibit the potential to constitute a promising multifunctional hemostatic reagent library.

Efficacy and Safety of Proactive Therapy with 2% Crisaborole Ointment in Children with Mild-to-Moderate Atopic Dermatitis: A Randomized Controlled Study.

Background: The effectiveness of crisaborole for proactive treatment of atopic dermatitis (AD) is not well established.

Objectives: This study aims to investigate the efficacy and safety of a proactive treatment strategy with 2% crisaborole ointment for managing mild-to-moderate AD in children.

Patients And Methods: In this 16-week randomized-controlled trial, children aged 2-17 years with mild-to-moderate AD were enrolled.

Hydrogen-Bonded Organic Framework Films Integrated with Wavy Structured Design for Wearable Bioelectronics.

The integration of hydrogen-bonded organic frameworks (HOFs) with flexible electronic technologies offers a promising strategy for monitoring detailed health information, owing to their inherent porosity, excellent biocompatibility, and tunable catalytic capabilities. However, their application in wearable and real-time health monitoring remains largely unexplored, primarily due to the mechanical mismatch between the traditionally fragile HOFs particles and the softness of human skin. Herein, this study demonstrates an epidermal biosensor that maintains reliable sensing capability even under extreme deformation and complex environmental conditions by integrating HOFs films with wavy bioelectrodes.

Age-related differences of subjective visual vertical perception in adults-a functional near-infrared spectroscopy study.

Background: The perception of Subjective Visual Vertical (SVV) is crucial for postural orientation and significantly reflects an individual's postural control ability, relying on vestibular, visual, and somatic sensory inputs to assess the Earth's gravity line. The neural mechanisms and aging effects on SVV perception, however, remain unclear.

Objective: This study seeks to examine aging-related changes in SVV perception and uncover its neurological underpinnings through functional near-infrared spectroscopy (fNIRS).

Stacking paper sheets into multi-purpose quick response sensing code with built-in nitrocellulose-membrane-free lateral flow assay for detecting tetracycline in food samples.

Lateral flow assays (LFAs) have found extensive applications in food safety and quality monitoring. Now, smartphone technology is redefining how tests are conducted at the point of use. At the same time, quick response (QR) codes enhance digital connectivity for information transmission, data collection, and response linkage.

Relationship between physicochemical properties, non-volatile substances, and microbial diversity during the processing of dry-cured Spanish mackerel.

To meet the demand of consumers for high-quality dry-cured fish. This study investigates the relationship between microbial diversity and the changes in physicochemical properties and non-volatile flavor compounds of dry-cured Spanish mackerel (DCSM) throughout the curing process. Our findings demonstrate that moisture content significantly decreased during curing, while NaCl generally increased.

In Situ Integration of Metallic Catalytic Sites and Photosensitive Centers within Covalent Organic Frameworks for the Enhanced Photocatalytic Reduction of CO.

Covalent organic frameworks (COFs) are a promising platform for heterogeneous photocatalysis due to their stability and design diversity, but their potential is often restricted by unmanageable targeted excitation and charge transfer. Herein, a bimetallic COF integrating photosensitizers and catalytic sites is designed to facilitate locally ultrafast charge transfer, aiming to improve the photocatalytic reduction of CO. The strategy uses a "one-pot" method to synthesize the bimetallic COF (termed PBCOF) through in situ Schiff-base condensation of Pyrene with MBpy (M = Ru, Re) units.

Relationship between leukocyte count and renal function in patients with lupus nephritis: a retrospective study of Chinese adults.

Objective: To explore the relationship between leukocyte count and renal function in patients with lupus nephritis (LN).

Methods: We performed a retrospective cross-sectional study of 100 patients with LN admitted to the Department of Nephrology between 1 January 2015 and 30 December 2023. Based on tertile of leukocyte count, they were allocated to Low, Medium, or High groups.

Induced Charge-Compensation Effect for Boosting Photocatalytic Water Splitting in Covalent Organic Frameworks.

Imine-based covalent organic frameworks (COFs) are promising for photocatalytic water splitting, but their performance is often constrained by inefficient charge separation due to the high electron localization nature of polar imine bonds. In this study, we have optimized the electron delocalization across the imine linkage within a COF by implementing a charge compensation effect. This effect is achieved when a strong electron-donating thieno[3,2-b]thiophene linker is directly attached to the iminic carbon of a zinc-porphyrinic COF.

Investigating the temporal evolution of physicochemical attributes and flavorome profiles in Sichuan shai vinegar utilizing diverse aging techniques.

Sichuan shai vinegar (SSV) is an acidic condiment with a long history and unique flavor. Aging is an important production process that determines the unique flavor of shai vinegar. This study compared the differences in physicochemical properties, volatile flavor, and non-volatile flavor substances between the constant temperature aging and natural aging methods of SSV Cupei.

Enhancing catalytic efficiency of GAO-5F from Fusarium odoratissimum and its application in development of a polyaldehyde crosslinked gelatin-based edible packaging film.

Galactose oxidase has long captured the interest of the biocatalysis and biotechnology communities due to its unique catalytic characteristics and versatility with various substrates. In our previous studies, we demonstrated that galactose oxidase GAO-5F from Fusarium odoratissimum can oxidize agarose to produce a polyaldehyde polymer, which can be further crosslinked with gelatin to produce food packaging films. Despite its commendable catalytic performance, GAO-5F falls short of meeting the requirements for industrial applications.

Ubiquitination and Metabolic Disease.

The increasing incidence of metabolic diseases, including obesity, type 2 diabetes mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD), in the past decade is a serious concern worldwide. Disruption of cellular protein homeostasis has been considered as a crucial contributor to the pathogenesis of metabolic diseases. To maintain protein homeostasis, cells have evolved multiple dynamic and self-regulating quality control processes to adapt new environmental conditions and prevent prolonged damage.

Triptolide induces hepatotoxicity by promoting ferroptosis through Nrf2 degradation.

Background: Triptolide (TP), a principal active substance from Tripterygium wilfordii, exhibits various pharmacological effects. However, its potential hepatotoxicity has always been a significant concern in clinical applications.

Purpose: This research aimed to explore the involvement of ferroptosis in TP-mediated hepatic injury and the underlying mechanisms.

Face emojis vs. Non-face emojis: Exploring neural mechanisms in text processing.

With the rapid development of digital communication, emojis have played an increasingly important role in computer-mediated communication (CMC). Although Non-face emojis account for approximately 90 % of emoji usage, related research remains relatively scarce. Furthermore, there is limited exploration of the differences in the mechanisms of text processing between Face and Non-face emojis.

Reverse magnetic resonance tuning nanoplatform with heightened sensitivity for non-invasively multiscale visualizing ferroptosis-based tumor sensitization therapy.

Ferroptosis-based therapy has garnered considerable attention for its ability to kill drug-resistant cancer cells. Consequently, it holds great significance to assess the therapeutic outcomes by monitoring ferroptosis-related biomarkers, which enables the provision of real-time pathological insights into disease progression. Nevertheless, conventional imaging technology suffers from limitations including reduced sensitivity and difficulty in achieving real-time precise monitoring.

Constructing Ag/CuO Interface for Efficient Neutral CO Electroreduction to CH.

Neutral CO electroreduction to multi-carbons (C) offers a promising pathway to reduce the CO and energy losses originating from the carbonate formation. However, the sluggish kinetics of C-C coupling brings a significant challenge of achieving high selectivity of a single product (such as ethylene), especially at industrial-relevant current densities (>300 mA cm). Here, we reported an optimized Ag-CuO interfacial catalyst that exhibited C Faradaic efficiency (FE) of 73.