Muscle path length in horizontal strabismus.

Background: Sarcomere adaptation has been proposed as a mechanism for the adjustment of rectus muscle length in regulating binocular alignment. The purpose of this study was to investigate whether horizontal rectus muscle paths have abnormal lengths in subjects with intermittent or alternating strabismus.

Methods: High-resolution, surface coil magnetic resonance imaging was obtained in 2 mm thick axial planes in strabismic patients who had not undergone prior surgery and normal control subjects.

Risk factors influencing the outcome of strabismus surgery following retinal detachment surgery with scleral buckle.

Purpose: To determine factors associated with surgical success in patients undergoing strabismus surgery after retinal detachment repair with scleral buckle.

Methods: The medical records of consecutive patients who underwent strabismus surgery after repair of retinal detachment with scleral buckle were retrospectively reviewed. A successful "motor" outcome was defined as horizontal deviation <10(Δ) and vertical deviation <4(Δ) in the primary position; successful "sensory" outcome was no diplopia in the primary position.

Avastin treatment reduces retinal neovascularization in a mouse model of retinopathy of prematurity.

Purpose: This study was designed to evaluate the effect of one intraperitoneal (IP) injection of bevacizumab (Avastin) on the severity of oxygen-induced retinopathy (OIR) in a mouse model.

Materials And Methods: Twenty-eight eyes of 14 mice with OIR were studied. There were nine mice in the bevacizumab-treated group (study group) and five mice in the saline-treated group (controls).

The effect of thalidomide on neovascularization in a mouse model of retinopathy of prematurity.

Purpose: Abnormal angiogenesis is the hallmark feature of retinopathy of prematurity (ROP), and contributes to the severe visual loss that accompanies this disease. Thalidomide is a well-known anti-angiogenic drug. We tested the assumption that injection of intraperitoneal thalidomide could reduce the severity of oxygen-induced retinopathy (OIR) in a mouse model.

COL11A2 mutation associated with autosomal recessive Weissenbacher-Zweymuller syndrome: molecular and clinical overlap with otospondylomegaepiphyseal dysplasia (OSMED).

Autosomal recessive Weissenbacher-Zweymuller syndrome (WZS) is a skeletal dysplasia characterized by rhizomelic dwarfism and severe hearing loss. Mutations in the COL11A2 gene have been implicated in causing the autosomal dominant form of this syndrome as well as non-ocular Stickler syndrome and the autosomal recessive syndrome otospondylomegaepiphyseal dysplasia (OSMED). In a consanguineous Bedouin tribe living in Southern Israel, five individuals affected by autosomal recessive WZS were available for genetic analysis.