Publications by authors named "Rondeep S Brar"
Article Synopsis
- Cyclic thrombocytopenia (CTP) is a rare condition characterized by fluctuating platelet counts, but its underlying causes are not well understood.
- A study analyzed two patients experiencing stable platelet and thrombopoietin (TPO) cycles, revealing that changes in specific blood genes precede platelet count fluctuations, suggesting a link between platelet production and count cycling.
- The research also uncovered new genetic mutations associated with CTP, including a loss-of-function mutation in the thrombopoietin receptor and gain-of-function variants in a key signaling protein, indicating potential pathways for understanding and treating the disease.
Background: The role of splenectomy to diagnose and treat hematologic disease continues to evolve. In this single-center retrospective review, we describe modern morbidity, mortality, and long-term outcomes associated with splenectomy for benign and malignant hematologic disorders.
Methods: We analyzed all nontrauma splenectomies performed for benign or malignant hematologic disorders from January 2009 to September 2018.