Acute Cytokine Response During Breast Cancer Surgery: Potential Role of Dexamethasone and Lidocaine and Relationship with Postoperative Pain and Complications - Analysis of Three Pooled Pilot Randomized Controlled Trials.

Purpose: An imbalance in perioperative cytokine response may cause acute pain and postoperative complications. Anesthetic drugs modulate this cytokine response, but their role in non-major breast cancer surgery is unclear. In an exploratory study, we investigated whether intravenous lidocaine and dexamethasone could modulate the cytokine response into an anti-inflammatory direction.

A comparison of postoperative throat and neck complaints after the use of the i-gel and the La Premiere disposable laryngeal mask: a double-blinded, randomized, controlled trial.

Background: Many supralaryngeal airway devices are available. Because of the absence of an inflatable cuff, we hypothesized that use of the i-gel should produce fewer postoperative throat and neck complaints compared with a standard disposable laryngeal mask (LM).

Methods: Two hundred eighteen patients were randomized to have either an i-gel or La Premiere LM airway placed for airway management.

Intraocular anti-Toxoplasma gondii IgA antibody production in patients with ocular toxoplasmosis.

Purpose: To investigate the immunoglobulin classes associated with the intraocular anti-Toxoplasma gondii antibody response during clinical ocular toxoplasmosis and to determine which immunoglobulin class is most helpful in the diagnosis of this disease.

Methods: Paired serum and intraocular fluid samples from 155 patients who had uveitis were tested for intraocular anti-T. gondii IgG, IgA, and IgM antibody production.

Aetiology of uveitis in Sierra Leone, west Africa.

Background: In 1992, non-onchocercal uveitis caused 9% of blindness, 8% of visual impairment, and 11% of uniocular blindness among patients visiting an eye hospital in Sierra Leone, west Africa. The aim of this study was to determine the aetiology of uveitis in this population.

Methods: General and ophthalmic examination complemented by serum and aqueous humour analyses for various infectious agents was performed for 93 uveitis patients and compared with serum (n = 100) and aqueous humour (n = 9) analysis of endemic controls.

Elevated serum angiotensin-converting enzyme activity in onchocerciasis.

Our objective was to measure serum angiotensin-converting enzyme (ACE) activity in patients with onchocerciasis. Serum ACE activity is commonly used in the diagnosis and follow-up of patients with sarcoidosis. However, serum ACE activity can also be elevated in a number of other granulomatous disorders.

Presumed acquired ocular toxoplasmosis.

Objective: To describe the clinical characteristics and laboratory findings of eight patients with focal chorioretinitis presumably caused by acquired toxoplasmosis.

Design: Case series.

Setting: Referral hospitals in the Netherlands.

Blindness from uveitis in a hospital population in Sierra Leone.

A retrospective study was conducted to assess the causes of blindness and visual impairment in patients who visited an eye hospital in Sierra Leone, West Africa, in 1989 and 1992. These data were compared with figures from 1981. Throughout the years, senile cataract was the major cause of blindness, followed by uveitis (including onchocerciasis).

[Unexpected movements in a brain-dead patient].

In a brain-dead patient, a 42-year-old woman who went into a coma after a cervical foraminotomy, spinal automatisms were seen which cast doubt on the diagnosis of brain death. The procedure which was to lead to organ transplantation was seriously disturbed. In brain-dead patients spinal automatisms appear earlier and are more often present than deep tendon reflexes.

Disconnection of the ventilatory system does not prevent pleural lesions during sternotomy.

In previous studies pleurotomy has seldom been reported as a complication of sternotomy and, therefore, the incidence is unknown. Factors increasing or decreasing the risk of pleurotomy also have not been studied properly. In a prospective, randomized trial, performed during 14 consecutive months from 1988 until 1989, the incidence of pleurotomy and its possible risk factors were studied in 712 patients undergoing median sternotomy for cardiac and mediastinal procedures.

Parasitological, clinical and haematological response of children with Plasmodium falciparum to 4-aminoquinolines and to pyrimethamine-sulfadoxine with quinine in western Kenya.

Children with Plasmodium falciparum infections in Western Province, Kenya, were studied in 1987 for their parasitological, clinical and haematological response to chloroquine, to amodiaquine and to pyrimethamine-sulfadoxine plus quinine. Ninety-eight children under 5 years of age were treated in 1 of 2 hospitals. Of the 56 patients treated with chloroquine base 25 mg/kg, 91% had resistant infections, with 36% having no significant decrease in parasitaemia (RIII resistance); however, 69% responded clinically within a week.