Publications by authors named "Ronda Pindzola"
Background And Purpose: Hemodynamic compromise in symptomatic patients with occlusive vascular disease (OVD) identified by cerebrovascular reserve (CVR) and oxygen extraction fraction (OEF) is an independent predictor of high stroke risk. However, up to 60% of patients compromised by CVR have normal OEF indicating a high rate of discordance. CVR is measured with an acetazolamide challenge, and OEF reactivity (OEFR) to acetazolamide, ie, a hemodynamic challenge, may reveal hemodynamic compromise and less discordance with measurements of CVR.
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- The study aims to identify stroke risk in patients with occlusive vascular disease by measuring oxygen extraction fraction (OEF) and cerebrovascular reserve (CVR).
- Many areas with compromised CVR aren't detected by OEF measurements, prompting researchers to evaluate oxygen extraction fraction response (OEFR) after administering acetazolamide.
- The findings revealed that positive OEFR could indicate hemodynamic compromise in areas with normal OEF, highlighting a correlation between OEFR and CVR in identifying at-risk brain regions.
Article Synopsis
- The study investigates the relationship between oxygen extraction fraction (OEF) and cerebrovascular reserve (CVR) in patients with carotid occlusion, noting discrepancies between regional and hemispheric assessments.
- The research involved measuring OEF and CVR in specific brain regions of 12 patients, highlighting how regional analysis decreased the discordance found in broader hemispheric comparisons.
- The findings suggest that while regional CVR can effectively identify areas with high OEF, further investigation is needed to assess the stroke risk associated with areas showing compromised CVR yet normal OEF.
Cerebrovascular reserve (CVR) and oxygen extraction fraction (OEF) are used to identify hemodynamic compromise in symptomatic patients with carotid occlusive vascular disease, but evidence suggests that they are not equivalent. The authors studied the relationship between CVR and OEF to evaluate their equivalence and stages of hemodynamic compromise. Symptomatic patients (N = 12) with carotid occlusion were studied by stable xenon-computed tomography CBF after intravenous acetazolamide administration for CVR, followed within 24 hours by positron emission tomography (PET) for OEF.
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