Trends and factors associated with dairy calf early slaughter in Ireland, 2018-2022.

Dairy systems require that each cow calves annually to have an efficient milk production cycle. In systems where milk production is maximized, the male offspring from dairy breed sires tend to have poor beef production traits and, therefore, can be of low economic value. Few studies have been published on the factors impacting early slaughtering of calves in peer-reviewed literature.

Selective photothermolysis with a novel 1726 nm laser beam: A safe and effective solution for acne vulgaris.

Background: Selective photothermolysis on sebaceous glands is an effective method for treating acne vulgaris (AV); however, safety, efficacy, and discomfort hinder its utilization in clinical settings.

Aims: The primary objective is to evaluate the safety and efficacy of a novel 1726 nm laser with contact cooling to treat AV.

Methods: Seventeen patients aged 18 to 36 were enrolled and treated in this IRB-approved, single-center, open-label study.

A Multi-Site, Single-Blinded, Prospective Pilot Clinical Trial for Non-Invasive Fat Reduction of the Abdomen and Flanks Using a Monopolar 2 MHz Radiofrequency Device.

Background And Objectives: Demand for non-invasive body sculpting procedures has been steadily increasing, spurring the development of new energy-based technologies. This study assessed the safety and efficacy of a new monopolar 2 MHz radiofrequency (RF) device for fat reduction of the flanks and abdomen.

Study Design/materials And Methods: Nineteen subjects from two clinical sites were enrolled in this study and received a single 15-minute treatment with the 2 MHz RF device.

Parents' experiences of transition from hospital to home of a child with complex health needs: A systematic literature review.

Aims And Objectives: To critically appraise primary research on the views and experiences of parents of children with complex health needs during the transition from hospital to home.

Background: Children with complex health needs frequently transition across and within healthcare systems, due to their age, care needs and ongoing health conditions. Repeated and unplanned admissions are significantly higher for children with complex health needs.

The Role of the Clinical Pharmacist in an Irish University Teaching Hospital: A Mixed-Methods Study.

Medication review (MR) is a vital part of the pharmacist's role in hospital. However, in the South Infirmary Victoria University Hospital (SIVUH), Cork, Ireland, this has not been fully implemented due to resource issues. In addition, the cost of providing this service has not been evaluated.

Histologic Characterization of Polymethylmethacrylate Dermal Filler Biostimulatory Properties in Human Skin.

Background: Little literature exits on the mechanism of action of implanted polymethylmethacrylate (PMMA) filler.

Objective: To characterize PMMA-induced dermal extracellular matrix production in the skin.

Materials And Methods: Single-center, open-label prospective study in healthy volunteers undergoing removal of redundant skin was injected intradermally and subdermally with PMMA dermal filler (Bellafill).

Isolation and characterization of a monoclonal antibody containing an extra heavy-light chain Fab arm.

Isolation and characterization of monoclonal antibody (mAb) variants to understand the impact of their structure on function is a typical activity during early-stage candidate selection that contributes to derisking clinical development. In particular, efforts are devoted to characterizing oligomeric variants, owing to their potential immunogenic nature. We report here a mAb variant consisting of a canonical mAb monomer associated in a non-covalent fashion with an antigen-binding fragment (Fab) arm amputated from its Fc domain.

Development of Home Educational Materials for Families of Preterm Infants.

Introduction: Parent educational materials describing infant positioning for a home program are vital in supplementing NICU discharge instructions and promoting parent confidence.

Purpose: To document the process of developing a brochure and DVD of a positioning program, using evidence-based practice and NICU expert feedback.

Methods: A trifold brochure and companion DVD were developed to demonstrate infant positioning to parents of premature infants for a home developmental program following NICU discharge.

Hyperthermic injury to adipocyte cells by selective heating of subcutaneous fat with a novel radiofrequency device: feasibility studies.

Background And Objective: The main objective of the present study is to demonstrate the feasibility of utilizing a novel non-invasive radiofrequency (RF) device to induce lethal thermal damage to subcutaneous adipose tissue only by establishing a controlled electric field that heats up fat preferentially.

Study Design/materials And Methods: Adipocyte cells in six-well plates were subjected to hyperthermic conditions: 45, 50, 55, 60, and 65 degrees C during 1, 2, and 3 minutes. Cell viability was assessed 72 hours after exposure.

Arsenic in the hair of the individuals in Santana-AP-Brazil: significance of residence location.

The concentration of arsenic in the hair of the individuals living in Santana city was measured. 121 donors in urban and the periphery area were studied. The periphery of the city shows the highest levels of arsenic (5.

Rehabilitation postfacial reanimation surgery after removal of acoustic neuroma: a case study.

Background And Purpose: Facial paralysis can have a significant negative impact on an individual's social, physical, and emotional well-being; however, little information has been reported on the efficacy of physical therapy interventions for this condition. The purpose of this case study was to describe the details of a physical therapy evaluation and intervention for a patient who underwent facial muscle transfer after resection of acoustic neuroma.

Case Description: A 29-year-old woman underwent left-sided facial reanimation surgery, which included transplantation of the temporalis muscle and platysma muscle to the corner of the mouth.

Mutational hot spot potential of a novel base pair mutation of the CSPG2 gene in a family with Wagner syndrome.

Objective: To report a 3-generation white family clinically diagnosed variably with Wagner, Stickler, and Jansen syndromes and screened for sequence variants in the COL2A1 and CSPG2 genes. Wagner syndrome is an autosomal dominant vitreoretinopathy with a predisposition to retinal detachment and cataracts. It has significant phenotypic overlap with allelic Jansen syndrome and ocular Stickler syndrome type 1.

Multiple intracranial meningiomas causing papilledema and visual loss in a patient with nevoid Basal cell carcinoma syndrome.

A 27-year-old man with nevoid basal cell carcinoma syndrome (NBCCS, Gorlin syndrome) who had undergone craniospinal irradiation for a childhood brain stem medulloblastoma complained of progressive binocular visual loss. Ophthalmologic examination disclosed subnormal visual acuity and visual fields in both eyes attributed to chronic papilledema. Brain MRI demonstrated mass effect from multiple large meningiomas.

Nonoperative management of spasticity in children.

Central to the longitudinal management of childhood hypertonia are nonsurgical treatments. These include physical and occupational therapy, electrical stimulation, orthotics, botulium toxin, and drugs. This manuscripts reviews these treatment modalities as well as evaluation tools available to assess their impact on a child's hypertonia.

Retinal pigment epithelium tears after intravitreal injection of bevacizumab (avastin) for neovascular age-related macular degeneration.

Background: Intravitreal bevacizumab (Avastin, Genentech, Inc., South San Francisco, CA) treatment of neovascular age-related macular degeneration (AMD) has become an important part of clinical retinal practice. We describe retinal pigment epithelium (RPE) tears that were noted after intravitreal injection of bevacizumab.

Senile panretinal cone dysfunction in age-related macular degeneration (AMD): a report of 52 amd patients compared to age-matched controls.

Purpose: To test if patients with age-related macular degeneration (AMD) have normal panretinal function using standardized full-field electroretinograms (ERGs).

Methods: This is a retrospective study evaluating electroretinographic studies performed in patients with AMD to assess their panretinal function. Fifty-two individuals 55 years or older had standardized ERG testing and fundus photographs.

X-linked high myopia associated with cone dysfunction.

Objective: Bornholm eye disease (BED) consists of X-linked high myopia, high cylinder, optic nerve hypoplasia, reduced electroretinographic flicker with abnormal photopic responses, and deuteranopia. The disease maps to chromosome Xq28 and is the first designated high-grade myopia locus (MYP1). We studied a second family from Minnesota with a similar X-linked phenotype, also of Danish descent.

New locus for autosomal dominant high myopia maps to the long arm of chromosome 17.

Purpose: To map the gene(s) associated with autosomal dominant (AD) high-grade myopia.

Methods: A multigeneration English/Canadian family with AD severe myopia was ascertained. Myopes were healthy, with no clinical evidence of syndromic disease, anterior segment abnormalities, or glaucoma.

Histological characteristics of metastasizing thin melanomas: a case-control study of 43 cases.

Objective: To study clinical and histological features associated with metastasizing thin melanomas (MTMs).

Design: Case-control study of clinicopathological features of patients with MTMs by a panel of 10 dermatopathologists.

Setting: Members of the North American Melanoma Pathology Study Group selected the cases from the melanoma databases at 8 academic institutions.

Clinical node-negative thick melanoma.

Background: Patients with T4 N0 M0 melanoma are considered at high risk for having occult metastases, and adjuvant therapy is usually recommended.

Hypothesis: Long-term survival in patients with thick melanoma is not universally poor.

Design: A retrospective study.

Further refinement of the MYP2 locus for autosomal dominant high myopia by linkage disequilibrium analysis.

Introduction: High myopia (>-6.00 diopters) is a complex common disorder that predisposes individuals to retinal detachment, glaucoma, macular degeneration, and premature cataracts. A recent linkage analysis of seven families with autosomal dominant high myopia has identified one locus (MYP2) for high myopia on chromosome 18p11.

Histologic criteria for the diagnosis of mycosis fungoides: proposal for a grading system to standardize pathology reporting.

Background: The histological diagnosis of early lesions of mycosis fungoides (MF) is often difficult for dermatopathologists and prior studies have shown a low agreement rate among pathologists. An important reason for such difficulty may be the lack of specific histological criteria.

Methods: We tested a new method to interpret and report biopsies suspicious for MF.

Coexistent cutaneous Aspergillus and cytomegalovirus infection in a liver transplant recipient.

Cutaneous infections are a significant cause of morbidity in solid organ recipients. These infections may be complex with multiple pathogens occurring in the same lesion. We describe the unusual association of cutaneous Aspergillus and cytomegalovirus (CMV) infections in a liver transplant recipient.