Publications by authors named "Ronan Joyce"
Hypofractionated Preoperative Radiation Therapy for Soft Tissue Sarcoma: A Systematic Review.
Int J Radiat Oncol Biol Phys
January 2025
Purpose: Hypofractionated radiation therapy is being used more frequently for many common cancer sites. Conventionally fractionated radiation therapy treatment regimens have remained the standard of care when radiation therapy is indicated for soft tissue sarcoma (STS). The aim of this study was to systematically review published data on the use of preoperative hypofractionated radiation therapy as part of a curative treatment paradigm in patients with STS.
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- The study evaluates an existing CT-based radiomic signature, originally developed for predicting HPV status in oropharyngeal cancer, to see if it can also apply to anal cancer.
- A dataset consisting of 59 patients was analyzed, and the radiomic model showed an AUC of 0.68 and an F1 score of 0.78, indicating moderate performance in predicting HPV status.
- The research suggests that this radiomic signature may be a valuable tool for identifying HPV status across different cancer types, highlighting its potential as a CT imaging biomarker.
Immune checkpoint inhibitors have transformed the treatment of advanced malignancy, while increasing the risk of immune-related adverse events. A 56-year-old woman who had received nivolumab for stage 4 renal cell carcinoma subsequently developed altered behaviour, memory deficits and worsening of previously stable epilepsy. MR scan of the brain showed bilateral FLAIR (fluid-attenuated inversion recovery) hyperintensity of the mesial temporal lobes, and there were anti-Ma2 antibodies in both serum and cerebrospinal fluid.
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