Background: Macrophages play important roles in phagocytosing tumor cells. However, tumors escape macrophage phagocytosis in part through the expression of anti-phagocytic signals, most commonly CD47. In Ewing sarcoma (ES), we found that tumor cells utilize dual mechanisms to evade macrophage clearance by simultaneously over-expressing CD47 and down-regulating cell surface calreticulin (csCRT), the pro-phagocytic signal.
View Article and Find Full Text PDFStudy Design: Systematic review.
Objective: Evaluate characteristics of patients with thoracolumbar injury classification and severity (TLICS) score of 4 (To4) severity traumatic thoracolumbar injury.
Summary Of Background Data: The TLICS score is used to predict the need for operative versus nonoperative management in adult patients with traumatic thoracolumbar injury.
Study Design: Systematic Review.
Objective: To elucidate treatment modalities and outcomes of patients with traumatic cervical spondyloptosis (TCS).
Summary: Traumatic cervical spondyloptosis (TCS) is rare and typically leads to devastating neurological injury.
Background: There are known classifications that describe thoracolumbar (TL) burst type injury but it is unclear which have the most influence on management. Our objective is to investigate the association of classification publications with the quantity and type of the most influential articles on TL burst fractures.
Methods: Web of Science was searched, and exclusion and inclusion criteria were used to extract the top 100 cited articles on TL burst fractures.
Background/aim: Resistance to glioblastoma (GB) therapy is attributed to the presence of glioblastoma stem cells (GSC). Here, we defined the behavior of GSC as it pertains to proliferation, migration, and angiogenesis.
Materials And Methods: Human-derived GSC were isolated and cultured from GB patient tumors.