Antibodies to dendritic neuronal surface antigens in opsoclonus myoclonus ataxia syndrome.

Opsoclonus myoclonus ataxia syndrome (OMAS) is an autoimmune disorder characterized by rapid, random, conjugate eye movements (opsoclonus), myoclonus, and ataxia. Given these symptoms, autoantibodies targeting the cerebellum or brainstem could mediate the disease or be markers of autoimmunity. In a subset of patients with OMAS, we identified such autoantibodies, which bind to non-synaptic puncta on the surface of live cultured cerebellar and brainstem neuronal dendrites.

Iris metastasis from systemic cancer in 104 patients: the 2014 Jerry A. Shields Lecture.

Purpose: To describe the clinical features, treatment, and outcome of patients with iris metastasis.

Methods: Retrospective case series of 160 tumors in 107 eyes of 104 patients with iris metastasis from systemic cancer.

Results: The median age at presentation with iris metastasis was 60 years.