Publications by authors named "Ronaldo da Silva Francisco"
Article Synopsis
- The study explores the prevalence of Mendelian kidney diseases among high-risk genotype individuals who underwent genetic testing in the U.S., revealing a lifetime kidney failure risk of about 15% for these patients.
- In a sample of 15,181 individuals, 20.5% were diagnosed with Mendelian kidney disease, and only 6.8% had high-risk genotypes, suggesting that other factors may influence disease progression.
- Among those of recent genomic African ancestry, the study found differing prevalence rates of pathogenic variants linked to high-risk and low-risk genotypes, indicating variability in genetic influence on kidney disease.
Article Synopsis
- During the first semester of 2021, Brazil faced a severe COVID-19 wave linked to the Gamma variant, with Delta variant cases emerging in July in Rio de Janeiro.
- Researchers analyzed over 1,600 genomic sequences of the Delta variant to understand its spread, noting its initial concentration in Rio de Janeiro city before reaching other areas.
- The Delta variant likely replaced Gamma due to a higher viral load, leading to increased case numbers but lower mortality rates, potentially aided by high vaccination rates in the region.
Genomic surveillance of SARS-CoV-2 tracks early interstate transmission of P.1 lineage and diversification within P.2 clade in Brazil.
PLoS Negl Trop Dis
October 2021
Article Synopsis
- * A study sequenced genomes from 185 samples across various Brazilian regions, revealing that P.1 and P.2 spread widely, with P.2 being dominant in most areas except Amazonas.
- * The research indicated that both variants originated in 2020 and emphasized the necessity for ongoing monitoring and control measures due to Brazil's high transmission rates.
Long-term infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents a challenge to virus dispersion and the control of coronavirus disease 2019 (COVID-19) pandemic. The reason why some people have prolonged infection and how the virus persists for so long are still not fully understood. Recent studies suggested that the accumulation of intra-host single nucleotide variants (iSNVs) over the course of the infection might play an important role in persistence as well as emergence of mutations of concern.
View Article and Find Full Text PDFExome-Wide Search for Genes Associated With Central Nervous System Inflammatory Demyelinating Diseases Following CHIKV Infection: The Tip of the Iceberg.
Front Genet
March 2021
Chikungunya virus (CHIKV) is a re-emergent arbovirus that causes a disease characterized primarily by fever, rash and severe persistent polyarthralgia, although <1% of cases develop severe neurological manifestations such as inflammatory demyelinating diseases (IDD) of the central nervous system (CNS) like acute disseminated encephalomyelitis (ADEM) and extensive transverse myelitis. Genetic factors associated with host response and disease severity are still poorly understood. In this study, we performed whole-exome sequencing (WES) to identify HLA alleles, genes and cellular pathways associated with CNS IDD clinical phenotype outcomes following CHIKV infection.
View Article and Find Full Text PDFArticle Synopsis
- Several studies identified new SARS-CoV-2 lineages that show unique genetic features and evolutionary differences.
- These findings highlight the ongoing mutation and adaptation of the virus.
- Understanding these new lineages is crucial for public health responses and vaccine development.
Emergence of novel SARS-CoV-2 lineages are under the spotlight of the media, scientific community and governments. Recent reports of novel variants in the United Kingdom, South Africa and Brazil (B.1.
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