NUT carcinoma, an under-recognized malignancy: a clinicopathologic and molecular series of 6 cases showing a subset of patients with better prognosis and a rare ZNF532::NUTM1 fusion.

NUT carcinoma (NC) is a rare malignancy with aggressive clinical behavior, defined by rearrangements involving the NUTM1 gene locus. This entity is often under-recognized and its diagnosis may be challenging. In this study, we describe a subset of patients that, despite the molecularly proven diagnosis of NC, show improved outcomes.

Endonasal endoscopic surgery for sinonasal squamous cell carcinoma from an oncological perspective.

Endonasal endoscopic surgery (EES) has been applied to the management of sinonasal (SN) tumors based on recent advances in endoscopic surgical techniques and technologies over the past three decades. EES has been mainly indicated for benign tumors and less aggressive malignant tumors. Notwithstanding this, EES has been gradually adopted for squamous cell carcinoma (SCC), which is the most common histology among SN malignancies.

Orbital exenteration for sinonasal malignancies: indications, rehabilitation and oncologic outcomes.

Purpose Of Review: Review the recent literature regarding the management of orbital invasion in sinonasal malignant tumors.

Recent Findings: There is a recent trend in preserving the orbit in cases of minimal invasion of periosteum and limited periorbit involvement, as well as in presence of good response to neoadjuvant chemotherapy, mainly in squamous cell carcinoma and neuroendocrine histologies.

Summary: The decision about orbital exenteration in cases of sinonasal malignancies is facilitated if the patient already has clear clinical signs of intraconal invasion such as visual loss, restriction of ocular mobility or infiltration of the eyeglobe.

The action of topical basic fibroblast growth factor in facial nerve regeneration.

Objective: To analyze the influence of the topical use of basic fibroblast growth factor (bFGF) in the regeneration of the facial nerve in rats.

Study Design: Experimental study.

Materials And Methods: Twenty-eight Wistar adult male rats underwent complete section of the facial nerve trunk, followed by end-to-end anastomosis with epineural sutures.

Influence of cyclic AMP on facial nerve regeneration in rats.

Unlabelled: Promoting facial nerve regeneration is a significant challenge.

Aim: To evaluate the possible neurotrophic influence of cyclic AMP on facial nerve regeneration of Wistar rats.

Method: The right facial nerve of thirty-two animals were completely transected and immediately sutured, followed by exposure or not to topical cyclic AMP.

Vocal fold immobility after thyroidectomy with intraoperative recurrent laryngeal nerve monitoring.

Context And Objective: Intraoperative nerve monitoring has emerged as a valuable tool to facilitate recurrent laryngeal nerve identification during thyroid surgery, thereby avoiding its injury. The aim was to evaluate vocal fold mobility in patients who underwent thyroidectomy with intraoperative nerve monitoring.

Design And Setting: Cohort formed by a consecutive series of patients, at a tertiary cancer hospital.

Sigmoid sinus thrombosis associated to chronic otitis media.

Unlabelled: Otogenous lateral sinus thrombosis (OLST) is a rare disease and presents a controversial treatment.

Aim: Clinical aspects and treatment were reported based on our experience.

Methods: Retrospective study.

Behavioral and histologic experimental model of facial nerve regeneration in rats.

Unlabelled: To setup an experimental model is the first step to study neural regeneration.

Aim: Setting up an experimental model on facial nerve regeneration.

Material And Methods: Wistar rats with complete sectioning and suturing of the extratemporal facial nerve trunk; with a behavioral and histological analysis for 9 weeks.

Standardization of techniques used in facial nerve section and facial movement evaluation in rats.

Aim: Standardization of the technique to section the extratemporal facial nerve in rats and creation of a scale to evaluate facial movements in these animals before and after surgery.

Study Design: Experimental.

Method: twenty Wistar rats were anesthetized with ketamine xylazine and submitted to sectioning of the facial nerve near its emergence through the mastoid foramen.

Voice and vocal self-assessment after thyroidectomy.

Background: Voice alterations after thyroidectomy can be found even with preserved function of laryngeal nerves. The purpose of this study was to evaluate voice before and after thyroid surgery and the role of orotracheal intubation on voice changes.

Methods: We conducted a prospective nonrandomized study of patients who underwent thyroid surgery and compared the results with a control group of patients who underwent breast surgery.

Clinical, etiological and progression factors of hearing in sudden deafness.

Unlabelled: Out of the many forms of therapy for sudden deafness, some require hospitalization and present significant risks.

Aim: This prospective study analyzes etiology and evolution in cases of sudden deafness (SD) where outpatient oral treatment was used.

Study Design: Clinical with transversal cohort.