Publications by authors named "Ronald W Kriz"
Article Synopsis
- BACE1 is an enzyme linked to Alzheimer's disease, and researchers are developing inhibitors by modifying peptides that interact with it.
- New methods were created to quickly analyze and improve these inhibitors, focusing on minimizing the peptide sequences needed for effective binding.
- The study successfully identified new "bis-statine" inhibitors with unique binding characteristics, showcasing peptide spot synthesis as a powerful approach for drug discovery.
MAP KAP kinase 2 (MK2), a Ser/Thr kinase, plays a crucial role in the inflammatory process. We have determined the crystal structures of a catalytically active C-terminal deletion form of human MK2, residues 41-364, in complex with staurosporine at 2.7 A and with ADP at 3.
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