Publications by authors named "Ronald Regino"
Article Synopsis
- Immunity plays a critical role in allergic diseases, as antibody responses to certain proteins can influence asthma presentation and immune system reactions.
- The study evaluated immune responses to two specific proteins, Asc l 5 and Al-CPI, in a population affected by asthma, utilizing ELISA to measure different antibody levels (IgE, IgG4, IgG).
- Findings indicated that while Al-CPI induced lower IgE levels, it resulted in higher IgG4 and IgG responses compared to Asc l 5, suggesting these proteins activate distinct immune responses that could impact asthma development.
Background: Asthma is not well investigated in equatorial Africa and little is known about the disease-associated allergen molecules recognized by IgE from patients in this area. The aim was to study the molecular IgE sensitization profile of asthmatic children and young adults in a semi-rural area (Lambaréné) of an equatorial African country (Gabon), to identify the most important allergen molecules associated with allergic asthma in equatorial Africa.
Methods: Fifty-nine asthmatic patients, mainly children and few young adults, were studied by skin prick testing to (Der p), (Der f), cat, dog, cockroach, grass, Alternaria and peanut.
Article Synopsis
- - The study focused on evaluating the allergenic properties of Blo t 2, a specific allergen from house dust mites, using both human and mouse models to assess its effects.
- - Results showed that sensitivity to Blo t 2 was comparable to another allergen, Blo t 21, but higher than Der p 2, with most patients having a low-intensity allergic response.
- - Immunization of mice with Blo t 2 led to significant allergic reactions, including skin inflammation and lung issues, confirming its allergenic activity and importance in clinical settings.
The severity of wheezing episodes is related with the need for health services, but the factors associated with health care utilization in preschool recurrent wheezers in underdeveloped regions are unclear. To evaluate the factors associated with health care utilization in preschool recurrent wheezers in Cartagena, Colombia. One hundred twenty-seven recurrent wheezers (age 2-6 years old) who were admitted to the emergency room (ER) due to wheezing in a Pediatric reference hospital in Cartagena were included.
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- COPD patients show significant differences in plasma protein levels compared to healthy controls, indicating a systemic inflammatory response that may increase their risk for severe COVID-19.
- Specifically, proteins like HGF and various chemokines are associated with this dysregulation, which may impact how their immune system responds to viral infections.
- The study also highlights elevated IL-6 levels in asthmatic patients, particularly females, suggesting that gender may play a role in their susceptibility to severe COVID-19 as well.*
To analyze the impact of infection on the pathogenesis and diagnosis of allergic diseases, new allergens should be identified. We report the identification of a new allergen, Asc l 5. The aim of this study was to evaluate the physicochemical and immunological features of the Asc l 5 allergen.
View Article and Find Full Text PDFSevere helminth infections are negatively associated to allergic diseases like asthma; therefore, the immunomodulatory properties of parasite-derived components have been analyzed, raising the possibility of their use as anti-inflammatory molecules. We evaluated the immunomodulatory properties of recombinant cysteine protease inhibitor (rAl-CPI) in a mouse model of allergic airway inflammation induced by the house dust mite (HDM) and its effects on human monocyte-derived dendritic cells (HmoDCs). The sensitized/challenged mice developed extensive cellular airway inflammatory response, which was significantly reduced upon treatment with rAl-CPI prior to sensitization, affecting particularly the perivascular/peribronchial infiltrate cells, eosinophils/neutrophils, and goblet cells.
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