Kinetic mechanisms by which nickel alters the calcium (Ca) transport in intact rat liver.

In the present work, the multiple-indicator dilution (MID) technique was used to investigate the kinetic mechanisms by which nickel (Ni) affects the calcium (Ca) transport in intact rat liver. Ca and extra- and intracellular space indicators were injected in livers perfused with 1 mM Ni, and the outflow profiles were analyzed by a mathematical model. For comparative purposes, the effects of norepinephrine were measured.

Sex differences in the development of hepatic steatosis in cafeteria diet-induced obesity in young mice.

The present study was planned to improve our understanding about sex differences in the development of hepatic steatosis in cafeteria diet-induced obesity in young mice. Female (FCaf) and male (MCaf) mice fed a cafeteria diet had similar body weight gain and adiposity index, but FCaf had a more extensive steatosis than MCaf. FCaf livers exhibited a higher non-alcoholic fatty liver disease activity score, elevated lipid percentage area (+34%) in Sudan III staining and increased TG content (+25%) compared to MCaf.