Publications by authors named "Ronald Muryellison Oliveira da Silva Gomes"
Group I introns are small RNAs (250-500 nt) capable of catalyzing their own splicing from the precursor RNA. They are widely distributed across the tree of life and have intricate relationships with their host genomes. In this work, we review its basic structure, self-splicing and its mechanisms of gene mobility.
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- The study focuses on the species complexes that cause cryptococcosis, highlighting variations in virulence and antifungal susceptibility based on fungal genotypes.
- It evaluates the presence of group I introns in mitochondrial genes across different isolates, using phylogenetic analysis to understand their origin and evolution.
- The findings reveal significant polymorphism in intron presence and size, showing that while it's difficult to distinguish cryptic species with a single intron, combining multiple PCR methods can differentiate genotypes within each species complex.
Invasive fungal infection by Cryptococcus neoformans var. grubii with bone marrow and meningeal involvement in a HIV-infected patient: a case report.
BMC Infect Dis
March 2019
Background: Cryptococcosis is a common opportunistic infection in patients infected by Human Immunodeficiency Virus (HIV) and is the second leading cause of mortality in Acquired Immunodeficiency Syndrome (AIDS) patients worldwide. The most frequent presentation of cryptococcal infection is subacute meningitis, especially in patients with a CD4+ T Lymphocytes count below 100 cells/μL. However, in severely immunosuppressed individuals Cryptococcus neoformans can infect virtually any human organ, including the bone marrow, which is a rare presentation of cryptococcosis.
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