Publications by authors named "Ronald Mooiweer"

Background: Simultaneous multi-slice (SMS) bSSFP imaging enables stress myocardial perfusion imaging with high spatial resolution and increased spatial coverage. Standard parallel imaging techniques (e.g.

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Background: Myocardial quantitative susceptibility mapping (QSM) may offer better specificity to iron than conventional T* imaging in the assessment of cardiac diseases, including intra-myocardial hemorrhage. However, the precision and repeatability of cardiac QSM have not yet been characterized. The aim of this study is to characterize these key metrics in a healthy volunteer cohort and show the feasibility of the method in patients.

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Radiofrequency catheter ablation is an established treatment strategy for ventricular tachycardia, but remains associated with a low success rate. MR guidance of ventricular tachycardia shows promises to improve the success rate of these procedures, especially due to its potential to provide real-time information on lesion formation using cardiac MR thermometry. Modern low field MRI scanners (<1 T) are of major interest for MR-guided ablations as the potential benefits include lower costs, increased patient access and device compatibility through reduced device-induced imaging artefacts and safety constraints.

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Purpose: MR-guided cardiac catheterization procedures currently use passive tracking approaches to follow a gadolinium-filled catheter balloon during catheter navigation. This requires frequent manual tracking and repositioning of the imaging slice during navigation. In this study, a novel framework for automatic real-time catheter tracking during MR-guided cardiac catheterization is presented.

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Purpose: To develop a motion-robust reconstruction technique for free-breathing cine imaging with multiple averages.

Method: Retrospective motion correction through multiple average k-space data elimination (REMAKE) was developed using iterative removal of k-space segments (from individual k-space samples) that contribute most to motion corruption while combining any remaining segments across multiple signal averages. A variant of REMAKE, termed REMAKE+, was developed to address any losses in SNR due to k-space information removal.

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Purpose: The MP2RAGE sequence is typically optimized for either T -weighted uniform image (UNI) or gray matter-dominant fluid and white matter suppression (FLAWS) contrast images. Here, the purpose was to optimize an MP2RAGE protocol at 7 Tesla to provide UNI and FLAWS images simultaneously in a clinically applicable acquisition time at <0.7 mm isotropic resolution.

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Cardiac MR thermometry shows promise for real-time guidance of radiofrequency ablation of cardiac arrhythmias. This technique uses ECG triggering, which can be unreliable in this situation. A prospective cardiac triggering method was developed for MR thermometry using the active tracking (AT) signal measured from catheter microcoils.

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Purpose: Universal Pulses (UPs) are excitation pulses that reduce the flip angle inhomogeneity in high field MRI systems without subject-specific optimization, originally developed for parallel transmit (PTX) systems at 7 T. We investigated the potential benefits of UPs for single channel (SC) transmit systems at 3 T, which are widely used for clinical and research imaging, and for which flip angle inhomogeneity can still be problematic.

Methods: SC-UPs were designed using a spiral nonselective k-space trajectory for brain imaging at 3 T using transmit field maps (B) and off-resonance maps (B) acquired on two different scanner types: a 'standard' single channel transmit system and a system with a PTX body coil.

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Purpose: We present in vivo testing of a parallel transmit system intended for interventional MR-guided cardiac procedures.

Methods: The parallel transmit system was connected in-line with a conventional 1.5 Tesla MRI system to transmit and receive on an 8-coil array.

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Article Synopsis
  • A new technology called fastNAV was developed to improve cardiac MR perfusion imaging by tracking respiratory motion specific to each patient.
  • The method uses a combination of different pulse techniques to minimize interference from respiratory motion, focusing on the right hemidiaphragm area for better image clarity.
  • Testing showed that fastNAV significantly improves image overlap and reduces displacement of the heart's center during scans, while maintaining consistent image quality compared to traditional imaging methods.
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A method is described to design parallel transmit (PTX) excitation pulses that are compatible with turbo spin echo (TSE) sequences, based on information available from conventional per-channel B mapping. The excitation phase of PTX pulses that generate a reduced field of excitation (rFOX) is matched to the phase the quadrature mode of a PTX coil. This enables TSE imaging of a PTX-enabled rFOX excitation combined with standard nonselective refocusing pulses transmitted in the quadrature mode.

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In parallel RF pulse design, peak RF magnitudes and specific absorption rate levels are critical concerns in the hardware and safety limits. The variable rate selective excitation (VERSE) method is an efficient technique to limit the peak RF power by applying a local-only RF and gradient waveform reshaping while retaining the on-resonance profile. The accuracy of the excitation performed by the VERSEd RF and gradient waveforms strictly depends on the performance of the employed hardware.

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Purpose: To show that a combination of parallel imaging using sensitivity encoding (SENSE) and inner volume imaging (IVI) combines the known benefits of both techniques. SENSE with a reduced field of excitation (rFOX) is termed rSENSE.

Theory And Methods: The noise level in SENSE reconstructions is reduced by removing voxels from the unfolding process that are rendered silent by using rFOX.

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Purpose: Aortic vessel wall imaging requires large coverage and a high spatial resolution, which makes it prohibitively time-consuming for clinical use. This work explores the feasibility of imaging the descending aorta in acceptable scan time, using two-dimensional (2D) spatially selective excitation and a new way of inversion recovery for black blood imaging.

Methods: The excitation pattern and field of view in a 3D gradient echo sequence are reduced in two dimensions, following the aorta's anisotropic geometry.

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