Hypermutation In Pancreatic Cancer.

Pancreatic cancer is molecularly diverse, with few effective therapies. Increased mutation burden and defective DNA repair are associated with response to immune checkpoint inhibitors in several other cancer types. We interrogated 385 pancreatic cancer genomes to define hypermutation and its causes.

Rasch-derived latent trait measurement of outcomes: insightful use leads to precision case management and evidence-based practices in functional healthcare.

The use of Rasch-derived latent trait measurement of outcomes for persons with chronic disease and disablement evolved from other fields, particularly education. Person-metrics is the measurement of how much chronic disease and disablement affects an individual's daily activities physically, cognitively, and through vocational and social role participation. The ability of the Rasch model to assume that the probability of a given person/item interaction is governed by the difficulty of the item and the ability of the person is invaluable to disability measurement.

The ISR: intelligent student reports.

Rasch-based Scale Scores are a simple linear transformation of the basic logit metric. Scale Scores are the quantification of the measurement continuum. This quantification makes it possible to do arithmetic, computer differences, and apply standard statistical techniques.