G6PDH as a key immunometabolic and redox trigger in arthropods.

The enzyme glucose-6-phosphate dehydrogenase (G6PDH) plays crucial roles in glucose homeostasis and the pentose phosphate pathway (PPP), being also involved in redox metabolism. The PPP is an important metabolic pathway that produces ribose and nicotinamide adenine dinucleotide phosphate (NADPH), which are essential for several physiologic and biochemical processes, such as the synthesis of fatty acids and nucleic acids. As a rate-limiting step in PPP, G6PDH is a highly conserved enzyme and its deficiency can lead to severe consequences for the organism, in particular for cell growth.

Differential expression of PEPCK isoforms is correlated to Aedes aegypti oogenesis and embryogenesis.

The mosquito Aedes aegypti undertakes a shift in carbohydrate metabolism during embryogenesis, including an increase in the activity of phosphoenolpyruvate carboxykinase (PEPCK), a key gluconeogenic enzyme, at critical steps of embryo development. All eukaryotes studied to date present two PEPCK isoforms, namely PEPCK-M (mitochondrial) and PEPCK-C (cytosolic). In A.

Reemerging diseases in Brazil: sociodemographic and epidemiological characteristics of syphilis and its under-reporting.

Introduction: This paper analyzed sociodemographic and epidemiological data of individuals with syphilis as well as the compulsory reporting of the disease, for being a reemerging disease in Brazil.

Methods: General information and sociodemographic, epidemiological, clinical, and laboratory data were verified in compulsory reporting.

Results: From 2010 to 2016, 157 reporting forms were explored.

Detection and genotyping of Trypanosoma cruzi from açai products commercialized in Rio de Janeiro and Pará, Brazil.

Background: Several cases of food-borne acute Chagas disease (ACD) have been reported in the Brazilian Amazon so far. Up to 2004, the occurrence of ACD by oral transmission, associated with food consumption, was rare. Recent cases of ACD in Brazil have been attributed to the consumption of juice from the açai palm containing reservoir animals or insect vectors waste, infected with Trypanosoma cruzi.

Sociodemographic and epidemiological profile of leprosy patients in an endemic region in Brazil.

Introduction:: The incidence of Hansen's disease is high in overlooked populations.

Methods:: Data of Hansen's disease cases reported in the information system of the Department of Informatics, Brazilian Unified Health System, from 2013 to 2014 were analyzed.

Results:: Among 434 studied cases of Hansen's disease, the female sex (52.

DENTISTS' KNOWLEDGE AND EXPERIENCE REGARDING LEPROSY IN AN ENDEMIC AREA IN BRAZIL.

This study aims to analyze the dental surgeons' knowledge about leprosy and its ways of transmission, clinical characteristics and treatment, besides analyzing their experience with respect to diagnostic suspicion and case referrals. The study population comprised 242 dental surgeons working in the public dental service of the city of Cuiabá, Mato Grosso, Brazil. A self-applicable questionnaire containing questions about the dental surgeon's profile was used, including his/her knowledge on leprosy, as well as his/her practices concerning the disease.

[Prevalence of temporomandibular disorders among industrialworkers. Association with stress and sleep disorder].

Objective To determine the presence of temporomandibular disorders (TMD), sleep disorders and stress, as well as the association between these factors, among industrial workers in São Paulo State, Brazil. Material and Methods Fonseca's questionnaire was used to verify the level of TMD, the Toronto Sleep Assessment Questionnaire (SAQ) was applied to check the quality and occurrence of sleep disorders, and the Social Readjustment Rating Scale (SRRS) was used to check the degree of stress. The data collected were tabulated with Epi InfoTM 7 and statistically analyzed using the chi-square test, with a 5 % significance level.

The stigma and prejudice of leprosy: influence on the human condition.

Introduction: To analyze the knowledge, feelings and perceptions involving patients affected by leprosy, as a better understanding of these factors may be useful to decrease the stigma and prejudice associated with the condition.

Methods: The study cohort consisted of 94 patients who underwent treatment for leprosy at the Health Units in the City of Cuiabá, Mato Grosso (MT), Brazil. The study questionnaire included items to collect information on socio-demographic data, knowledge about the disease, stigma, prejudice, self-esteem and quality of life of leprosy patients.

Adherence to standard precautions from the standpoint of the Health Belief Model: the practice of recapping needles.

The aim of this study was to apply the Health Belief Model to explain the adherence to the recommendation not to recap needles by dentists and dental assistants of the public health system in a municipality in the State of São Paulo. A questionnaire validated and adapted for the oral health area was used, which included variables related to the frequency of recapping and health beliefs using Likert-type scales. The relationship between beliefs and adherence to the recommendation not to recap needles was obtained by regression analysis.

[Prevalence of non-nutritive sucking habits in preschoolers and parents' perception of its relationship with malocclusions].

This cross-sectional and descriptive study sought to verify the prevalence of sucking habits in preschoolers and their parents' perception of its relationship with the occurrence of malocclusion. The population consisted of a representative sample of parents of preschoolers aged between 4 months and 6 years old. A semi-structured, self-administered questionnaire was used, consisting of open and closed questions relating to frequency of use and knowledge of parents regarding non-nutritive sucking habits.

[The relation between socio-economic class and demographic factors in the occurrence of temporomandibular joint dysfunction].

Different factors like stress and occlusion can decrease the adaptive capacity of the stomatognathic system and lead to the occurrence of temporomandibular dysfunction (TMD). The objective of this study was to verify the relation of the variables socio-economic level, schooling, sex and age with the occurrence of temporomandibular dysfunction. The population of this study consisted of a statistically significant sample of subjects of both sexes belonging to different socio-economic classes living in the urban area of the city of Piacatu, São Paulo, Brazil.

[Declining caries rate in a municipality in northwestern São Paulo State, Brazil, 1998-2004].

This study analyzes the DMF and DEF indices, SiC index, and percentage of caries-free public schoolchildren in the municipality of Bilac, São Paulo State, Brazil, in 1998, 2000, 2002, and 2004. The same methodology was employed (WHO-1997) in all the surveys. Kappa test was carried out at each stage, and the minimal and maximum inter-examiner agreement values obtained were 0.