Critical incident stress management in a school setting following police shooting of an adolescent.

Cincinnati Public Schools Critical Incident Stress Management Team responded when a teenager who was in possession of a pellet gun was killed by police. The themes that emerged had more to do with rage than typical bereavement or trauma responses. The primary objective was the prevention of school and community violence.

Pharmacokinetics of trazodone and its major metabolite m-chlorophenylpiperazine in plasma and brain of rats.

Sprague-Dawley rats were used as models for single trazodone administration (males), continuous adminstration and dose proportionality experiments (males, females, pregnant females). Plasma and brain tissue were analysed for trazodone and its active metabolite, m-chlorophenylpiperazine (m-CPP). Fetal exposure to trazodone and m-CPP was assessed and differences in their steady-state plasma concentration were sought between adult males and females.