ICU nutrition research: did the evidence get better? Remaining sources of bias.

Purpose Of The Review: To assess the quality of recently published (18 months from date of article request) randomized trials/systematic reviews of such trials that addressed the use of nutritional support in critically ill patients.

Recent Findings: Eligible papers were published between October 1, 2022 and April 7, 2024, only enrolled adults, described a comparison of a nutritional intervention to something else, and reported a clinically relevant outcome. Thirteen randomized trials and four systematic reviews of randomized trials were identified.

Nutritional support in liver disease - an updated systematic review.

Purpose Of Review: The association of malnutrition and a poor prognosis does not prove that providing nutrition support improves that prognosis. The proof of such efficacy requires its demonstration in well designed and executed randomized trials. A systematic review of 40 such trials in 2014 failed to make such a finding.

Aspirin use is associated with reduced risk for hepatocellular carcinoma.

Wang Y, Wang M, Liu C, et al. J Clin Gastroenterol. 2022.