Efficacy of Felpreva®, a new spot-on formulation containing tigolaner, emodepside and praziquantel, applied as a single application to cats artificially infested with ear mites ().

The efficacy of Felpreva® (Vetoquinol), a new spot-on application containing the novel acaricide and insecticide tigolaner in combination with emodepside and praziquantel, was evaluated in cats artificially infested with ear mites (). A total of three pivotal dose confirmation studies were conducted, two of them designed as non-interference studies. Cats were artificially infested with mites and randomly allocated into groups of 8 cats based on pre-treatment mite counts.

Observations on macrolide resistance and susceptibility testing performance in field isolates collected from clinical bovine respiratory disease cases.

The objectives of this study were; first, to describe gamithromycin susceptibility of Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni isolated from cattle diagnosed with bovine respiratory disease (BRD) and previously treated with either gamithromycin for control of BRD (mass medication=MM) or sham-saline injected (control=CON); second, to describe the macrolide resistance genes present in genetically typed M. haemolytica isolates; third, use whole-genome sequencing (WGS) to correlate the phenotypic resistance and genetic determinants for resistance among M. haemolytica isolates.

Disposition of gamithromycin in plasma, pulmonary epithelial lining fluid, bronchoalveolar cells, and lung tissue in cattle.

Objective: To determine the disposition of gamithromycin in plasma, pulmonary epithelial lining fluid (PELF), bronchoalveolar lavage (BAL) cells, and lung tissue homogenate in cattle.

Animals: 33 healthy Angus calves approximately 7 to 8 months of age.

Procedures: Calves were randomly assigned to 1 of 11 groups consisting of 3 calves each, which differed with respect to sample collection times.

Pharmacokinetics of firocoxib after administration of multiple consecutive daily doses to horses.

Objective: To determine pharmacokinetic parameters and variables, firocoxib concentrations in urine and plasma, urine-to-plasma ratios, and the urine depletion profile of firocoxib and to evaluate whether the pharmacokinetic behavior of firocoxib was governed by linear processes after multiple doses of firocoxib were administered IV and orally.

Animals: 6 healthy female horses (5 Paint horses and 1 Quarter Horse) in experiment 1 and 12 healthy male and female horses in experiment 2.

Procedures: In experiment 1, 6 horses were orally administered firocoxib paste once daily for 12 consecutive days, and plasma and urine samples were obtained and analyzed.

Pharmacokinetics of intravenously administered caffeine in healthy alpacas (Lama pacos) and llamas (Lama glama).

Objective: To determine the pharmacokinetic disposition of IV administered caffeine in healthy Lama spp camelids.

Animals: 4 adult male alpacas and 4 adult female llamas.

Procedures: Caffeine (3 mg/kg) was administered as an IV bolus.

Risk of after-hours visits to an in-hospital food animal service by species.

Computer records were accessed documenting in-hospital accessions to the food animal service maintained by the University of Missouri, College of Veterinary Medicine between January 1, 2001 and December 6, 2004. For each species category, the prevalence and relative risk (RR) of after-hours admission were calculated. The prevalence of after-hours visits varied from 0.

Effects of phenylbutazone alone or in combination with flunixin meglumine on blood protein concentrations in horses.

Objective: To assess effects of treatment with phenylbutazone (PBZ) or a combination of PBZ and flunixin meglumine in horses.

Animals: 24 adult horses.

Procedure: 13 horses received nonsteroidal antiinflammatory drugs (NSAIDs) in a crossover design.

Evaluation of a continuous glucose monitoring system for use in veterinary medicine.

Background: With the emergence of continuous glucose monitoring systems being used to provide a detailed glucose picture in humans, a commercially available system (CGMS(R), Medtronic Minimed, Northridge, CA) was examined for use in veterinary species.

Methods: Adult, clinically normal horses (n = 7), cats (n = 3), dogs (n = 4), and cows (n = 5) were studied. Cats (n = 4), dogs (n = 5), and one horse with diabetes were included in the study.

Comparison of the response of primary human blood monocytes and the U937 human monocytic cell line to two different sizes of alumina ceramic particles.

It is well recognized that wear particles derived from orthopaedic implants have the potential to induce inflammation, which may eventually lead to aseptic loosening of the artificial joint. We hypothesized that alumina ceramic particles of different sizes cause a differential cytokine response by human monocytes. To test this hypothesis a human monocytic cell line (U937) and primary human blood monocytes obtained from healthy volunteers were exposed to ceramic particles within the range known to be generated in vivo.

Comparison of refractometers and test endpoints in the measurement of serum protein concentration to assess passive transfer status in calves.

Objective: To evaluate 3 refractometers for detection of failure of passive transfer (FPT) of immunity in calves, and assess the effect of refractometric test endpoints on sensitivity, specificity, and proportion of calves classified correctly with regard to passive transfer status.

Design: Prospective study.

Animals: 90 calves.

Serum immunoglobulin G concentrations in calves fed fresh colostrum or a colostrum supplement.

This study compared serum immunoglobulin G (IgG) concentrations in calves fed colostrum with those of calves fed a colostrum supplement containing spray-dried serum. Twenty-four Holstein calves were randomly assigned to I of 2 treatment groups (fresh colostrum or colostrum supplement). Each calf was fed 4 L of colostrum (n, = 12) or 4 L of colostrum supplement (n2 = 12) via oroesophageal intubation at 3 hours of age.