Publications by authors named "Ronald J Mascarenhas"

Procaine hydrochloride (P.HCl) is one of the earliest and most well-established local anesthetic drugs used in medicine. Though it is employed frequently for effective clinical nerve blocks during surgeries, its immoderate administration has often shown reports of systemic toxicity.

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The leading cause of gynecological cancer-related morbidity and mortality is ovarian cancer (OC), which is dubbed a silent killer. Currently, OC is a target of intense biomarker research, because it is often not discovered until the disease is advanced. The goal of OC research is to develop effective tests using biomarkers that can detect the disease at the earliest stages, which would eventually decrease the mortality, thereby preventing recurrence.

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The use of the herbicide aminotriazole (3-ATA) in agriculture poses rising concerns about global water-borne contamination. Due to its toxicity which is known to cause cancer and thyroid dysfunction, 3-ATA is considered an important analytical target. Environmental protection agencies worldwide have introduced several directives that set concentration limits for chemicals to combat water pollution.

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Diabetes mellitus is a physiological and metabolic disorder affecting millions of people worldwide, associated with global morbidity, mortality, and financial expenses. Long-term complications can be avoided by frequent, continuous self-monitoring of blood glucose. Therefore, this review summarizes the current state-of-art glycemic control regimes involving measurement approaches and basic concepts.

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Health care monitoring is an extremely important aspect of human life that can be accomplished using wearable skin-patchable sensors. Upon interfacing with the skin or epidermal surface of the body, the sensing patches can monitor the movements of human parts such joints, legs, and fingers as well as tiny vibrations caused by respiration, blood flow, and heart beat. Wearable skin patches have shown improved promise in monitoring the body temperature and fever in addition to quick measurement of blood pressure and pulse rate along with breathing rate.

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The application of Propyl Paraben (PP) as a chemical preservative has expanded and diversified. Widespread use of products containing PP has resulted in its ubiquitous occurrence in environment and biological fluids among the general population. Several in-vivo studies have associated PP with estrogenic activity and malfunctioning of reproductive organs.

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Due to the enforcement of regulatory restrictions to prevent risk to human health from Bisphenol A (BPA), its structural analogue Bisphenol F (BPF) has been introduced into the market as an alternative. But however recent studies describe BPF as an effectual endocrine disruptor. Hence, there is an indispensible need for research concerning BPF human and environmental exposure level.

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The fabrication of differential pulse voltametry (DPV) sensor for the effective detection of Quercetin (QR) was achieved by modifying carbon paste electrode (CPE) with Iron decorated multi walled carbon nano tubes (Fe-MWCNTs) followed by drop casting of hexadecyltrimethylammonium bromide onto the surface for optimal results. Cyclic voltammetry and DPV techniques were used for qualitative and quantitative analysis of QR (Quercetin) respectively. The sensor revealed impressive electro-catalytic behavior towards oxidation of QR with almost 6.

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Free radicals are formed as byproducts of metabolism, and are highly unstable due to the presence of unpaired electrons. They readily react with other important cellular components such as DNA causing them damage. Antioxidants such as (+)-catechin (CAT), neutralize free radicals in the blood stream.

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Iron nanoparticles decorated multi-wall carbon nanotubes modified carbon paste electrode (Fe-MWCNTs/MCPE) was prepared by bulk-modification method. The electrochemical impedance spectroscopy (EIS) suggests least charge transfer resistance at the modified electrode. The electrochemical behavior of UA was studied in 0.

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An amperometric sensor for the determination of epinephrine (EP) was fabricated by modifying the carbon paste electrode (CPE) with pristine multi-walled carbon nanotubes (pMWCNTs) using bulk modification followed by drop casting of sodium dodecyl sulfate (SDS) onto the surface for its optimal potential application. The modified electrode showed an excellent electrocatalytic activity towards EP by decreasing the overpotential and greatly enhancing the current sensitivity. FE-SEM images confirmed the dispersion of pMWCNTs in the CPE matrix.

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A modified carbon paste electrode (CPE) for the selective detection of dopamine (DA) in presence of large excess of ascorbic acid (AA) and uric acid (UA) at physiological pH has been fabricated by bulk modification of CPE with multi-walled carbon nanotubes (MWCNTs) followed by electropolymerization of glycine (Gly). The surface morphology is compared using SEM images. The presence of nitrogen was confirmed by the energy dispersion X-ray spectroscopy (EDS) indicating the polymerization of Gly on the surface of the modified electrode.

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A biocompatible electrochemical sensor for selective detection of epinephrine (EP) in the presence of 1000-fold excess of ascorbic acid (AA) and uric acid (UA) was fabricated by modifying the carbon paste electrode (CPE) with multi-walled carbon nanotubes (MWCNTs) using a casting method. The electro-catalytic activity of the modified electrode for the oxidation of EP was investigated. The current sensitivity of EP was enhanced to about five times upon modification.

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An electrochemical sensor for the amperometric determination of L-tryptophan (Trp) was fabricated by modifying the carbon paste electrode (CPE) with multi-walled carbon nanotubes (MWCNTs) using drop cast method. 4.0 μL of the dispersion containing 2.

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An electrochemical sensor for sensitive detection of acetaminophen (AAP) was developed by electropolymerizing Patton and Reeder's reagent at carbon paste electrode (CPE). Modification improves the redox kinetics of AAP with increased current sensitivity. A similar modification at multiwall carbon nanotube (MWCNT) modified CPE did not result in an impressive charge transfer.

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A wax-impregnated carbon paste electrode with mercury oxalate as the bulk modifier is found to be suitable for the determination of heavy metal ions by differential pulse anodic stripping voltammetry. The contents of binder and modifier have been optimized, until they showed low background current and easy renewability. The bulk-modified electrode is applied for the simultaneous determination of Zn, Cd, Pb and Cu in medicinal plants and Ayurvedic tablets (Liv 52).

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