Publications by authors named "Ronald Gunn"
Bioavailability of epinephrine from Auvi-Q compared with EpiPen.
Ann Allergy Asthma Immunol
August 2013
Article Synopsis
- Epinephrine autoinjectors like Auvi-Q and EpiPen are both effective in delivering 0.3 mg of epinephrine for anaphylaxis, but Auvi-Q was designed to be easier to use.
- A study involving 71 healthy adults compared the bioavailability of epinephrine from both devices, measuring peak plasma concentration and overall exposure.
- Results showed that both devices produced similar levels of epinephrine in the body and had comparable safety profiles, with most adverse effects being mild and resolving on their own.
Design validation and labeling comprehension study for a new epinephrine autoinjector.
Ann Allergy Asthma Immunol
March 2013
Article Synopsis
- A novel epinephrine autoinjector (Auvi-Q) was created to reduce user mistakes and improve safety for patients and caregivers.
- The study tested the effectiveness of the patient information leaflet (PIL) in helping 20 adults and 20 children correctly use Auvi-Q through simulated injections, relying solely on the provided instructions.
- Results showed that most participants successfully completed the injection on their first try, indicating that the PIL and labeling effectively communicated the necessary steps for safe and proper use of the device.
Background: There is limited information regarding the effects of IGF-I and/or IGFBP-3 on circulating leptin concentrations.
Aim: To determine the effects of IGF-I on leptin and insulin concentrations, we examined leptin and insulin nocturnal profiles before and after the administration of the IGF-I/IGFBP-3 complex (Iplex) to prepubertal, low birth weight children.
Methods: We studied 20 prepubertal children (11 boys and 9 girls), born after a full-term pregnancy with a mean birth weight below 2.
Objective: There is limited information regarding the effects of IGF-I and/or IGFBP-3 on circulating ghrelin concentrations. To determine the effects of IGF-I on GH and ghrelin concentrations, we examined the GH and ghrelin nocturnal profiles before and after the administration of the IGF-I/-IGFBP-3 complex (Iplex) to low birth weight children.
Design: The children were studied on two separate occasions, the first under basal conditions, and the second time after the sc administration of 1 mg/kg of Iplex at 2100 h.
Background: The lack of catch up growth (CUG) in small for gestational age (SGA) children may be related to a reduced sensitivity to insulin growth factor 1 (IGF-I).
Aim: To assess the sensitivity to IGF-I in small for gestational age children, measuring basal and post IGF-I nocturnal profile of growth hormone (GH).
Patients And Methods: We studied 34 prepubertal SGA children aged 4 to 11 years.
Objective: To determine whether the administration of D-chiro-inositol, a putative insulin-sensitizing drug, would affect the concentration of circulating insulin, the levels of serum androgens, and the frequency of ovulation in lean women with the polycystic ovary syndrome.
Methods: In 20 lean women (body mass index, 20.0 to 24.