Risk factors associated with the development of infection with linezolid- and vancomycin-resistant Enterococcus faecium.

This retrospective cohort study revealed that linezolid resistance in vancomycin-resistant Enterococcus faecium was dependent on prior linezolid exposure and duration of linezolid therapy. These strains of E. faecium were resistant to the entire class of oxazolidinones.