Publications by authors named "Ronald Carrera"
Dysregulated host responses to infection can lead to organ dysfunction and sepsis, causing millions of global deaths each year. To alleviate this burden, improved prognostication and biomarkers of response are urgently needed. We investigated the use of whole-blood transcriptomics for stratification of patients with severe infection by integrating data from 3149 samples from patients with sepsis due to community-acquired pneumonia or fecal peritonitis admitted to intensive care and healthy individuals into a gene expression reference map.
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- - The text discusses how improvements in short-term recovery from severe trauma can be diminished by a systemic inflammatory response, which leads to infections and complications due to low levels of the steroid DHEA, known to enhance immune function.
- - The main goal of the study is to determine the appropriate dose of DHEA supplementation for trauma patients to improve their DHEA levels and explore its effects on immune response and metabolic profiles.
- - A randomized trial will involve up to 270 patients and examine different administration routes (oral vs sublingual) and dosages over three days, focusing on specific age groups and injury severity scores.