Publications by authors named "Ronald C Cason"
Background: Effective new agents for patients with colorectal cancer (CRC) with disease progression during standard therapy regimens are needed. We hypothesized that poly ADP ribose polymerase (PARP) inhibitor therapy in patients with CRC and inefficient tumor DNA repair mechanisms, such as those with high-level microsatellite instability (MSI-H), would result in synthetic lethality.
Methods: This was an open-label phase II trial testing olaparib 400 mg p.
Lymphomatoid papulosis (LyP) lies within the spectrum of primary cutaneous CD30-positive lymphoproliferative disorders. Approximately 10% to 15% of patients with LyP develop other lymphomas, most commonly mycosis fungoides (MF), suggesting a biological relationship between these distinctive diseases. Here, we describe the clinical and histopathologic features of 11 patients who had both LyP and MF, including a total of 30 biopsy specimens (14 LyP and 16 MF).
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- Primary cutaneous carcinosarcoma is a rare tumor that shows characteristics of both epithelial (skin-related) and sarcomatous (connective tissue-related) tissues, and its origins are not well understood.
- Researchers analyzed a case of this tumor using various techniques, including histology, immunohistochemistry, and advanced gene sequencing, to understand the differences and similarities between its two components.
- The findings indicated that both tumor components likely share a common origin, supported by similar genetic mutations, specific cell markers, and overlapping structural features in individual cells.