Publications by authors named "Ron Yefet"
Article Synopsis
- Stress-induced activation of β2-adrenergic receptors (β2AR) in B cells leads to increased IgG secretion but results in lower surface IgG expression and reduced B cell expansion.
- In mice, β2AR activation after immunization with ovalbumin or SARS-CoV-2 RBD enhances the binding of IgG to the target while blocking β2AR eliminates these effects.
- The study also shows that β2AR activation significantly boosts the affinity of monoclonal antibodies produced by B cells from convalescent SARS-CoV-2 donors, linking these changes to enhanced B cell receptor signaling and increased cell mobility.
Monkeypox virus (MPXV) resides in two forms; mature and enveloped, and depending on it, distinct proteins are displayed on the viral surface. Here, we expressed two MPXV antigens from the mature, and one from the enveloped form, and tested their reactivity to sera of 11 MPXV recoverees while comparing to sera from recently and past vaccinated individuals. 8 out of 11 recoverees exhibited detectable neutralization levels against Vaccinia Lister.
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