Lipopolysaccharide-induced changes in rat gastric H/K-ATPase expression.

Objective: To evaluate lipopolysaccharide (LPS)-induced inhibition of gastric acid secretion.

Summary Background Data: Endotoxemia from LPS inhibits gastric acid secretion by an unknown mechanism. Bacterial overgrowth in the stomach caused by decreased acid secretion could be responsible for nosocomial pneumonia developing in critically ill intensive care unit patients.