Publications by authors named "Ron S Briode"
Exploring the effects of extracranial injections of botulinum toxin type A on activation and sensitization of central trigeminovascular neurons by cortical spreading depression in male and female rats.
Agustin Melo-Carrillo Andrew M Strassman Khrystoffer-Kihan J Malcolm Aubrey Manack Adams Brett Dabruzzo Ron S Briode
Cephalalgia
September 2024
Article Synopsis
- OnabotulinumtoxinA (onabotA) is believed to help reduce migraine symptoms by blocking certain nerve pathways during their activation process in the brain and spinal cord.
- A study was conducted on anesthetized rats to observe how onabotA injections affected the activation of specific nerve cells in response to a triggering event called cortical spreading depression (CSD).
- Results showed that onabotA significantly reduced activation in wide-dynamic range neurons, preventing enhanced responses to mechanical stimuli, indicating its effectiveness in moderating migraine-related nerve sensitivity.