Three pigeons were exposed to second-order schedules in which responding under a fixed-interval (FI) component schedule was reinforced according to a variable-interval (VI) schedule of food reinforcement. Completion of each component resulted in either (1) brief presentation of a stimulus present during reinforcement (paired brief stimulus), (2) brief presentation of a stimulus not present during reinforcement (nonpaired brief stimulus), or (3) no stimulus presentation (tandem schedule). Under the two nonpaired brief stimulus conditions, either a change in keylight color or onset of houselight illumination was used as the brief stimulus.
View Article and Find Full Text PDFMacrophage plasticity is critical for normal tissue repair to ensure transition from the inflammatory to the proliferative phase of healing. We examined macrophages isolated from wounds of patients afflicted with diabetes and of healthy controls and found differential expression of the methyltransferase Setdb2. Myeloid-specific deletion of Setdb2 impaired the transition of macrophages from an inflammatory phenotype to a reparative one in normal wound healing.
View Article and Find Full Text PDFControl of inflammation is critical for the treatment of nonhealing wounds, but a delicate balance exists between early inflammation that is essential for normal tissue repair and the pathologic inflammation that can occur later in the repair process. This necessitates the development of novel therapies that can target inflammation at the appropriate time during repair. Here, we found that SIRT3 is essential for normal healing and regulates inflammation in wound macrophages after injury.
View Article and Find Full Text PDFDeep-vein thrombosis (DVT) resolves via a sterile inflammatory response. Defining the inflammatory response of DVT may allow for new therapies that do not involve anticoagulation. Previously, we have shown that Toll-like receptor 9 (Tlr9) gene deleted mice had impaired venous thrombosis (VT) resolution.
View Article and Find Full Text PDFToll-like receptor (TLR) activation has been implicated in acetaminophen (APAP)-induced hepatotoxicity. Herein, we hypothesize that TLR3 activation significantly contributed to APAP-induced liver injury. In fasted wildtype (WT) mice, APAP caused significant cellular necrosis, edema, and inflammation in the liver, and the de novo expression and activation of TLR3 was found to be necessary for APAP-induced liver failure.
View Article and Find Full Text PDFC57BL/6 mice were maintained for up to 18 months on high-fat and low-fat diets with or without a multi-mineral supplement derived from the skeletal remains of the red marine algae Lithothamnion calcareum. Numerous grossly observable liver masses were visible in animals on the "western-style" high-fat diet sacrificed at 12 and 18 months. The majority of the masses were in male mice (20 out of 100 males versus 3 out of 100 females; p = 0.
View Article and Find Full Text PDFJ Exp Anal Behav
September 2008
Pigeons' keypecking was maintained under two- and three-component chained schedules of food presentation. The component schedules were all fixed-interval schedules of either 1- or 2-min duration. Across conditions the presence of houselight illumination within each component schedule was manipulated.
View Article and Find Full Text PDFJ Exp Anal Behav
January 2008
Adjunctive or induced behavior is generated during a variety of schedules of reinforcement. Several theoretical conceptualizations suggest that rate of reinforcement is the primary variable controlling the strength or levels of induced behavior. The operant response requirement within the schedule context has not been extensively studied as a determinant of induced responding.
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