Correction: Winkler et al. The Adhesion G-Protein-Coupled Receptor GPR115/ Regulates Epidermal Differentiation and Associates with Cytoskeletal KRT1. 2022, , 3151.

In the original publication [...

The Adhesion G-Protein-Coupled Receptor GPR115/ Regulates Epidermal Differentiation and Associates with Cytoskeletal KRT1.

Among the 33 human adhesion G-protein-coupled receptors (aGPCRs), a unique subfamily of GPCRs, only , encoding GPR115, shows an obvious skin-dominated transcriptomic profile, but its expression and function in skin is largely unknown. Here, we report that GPR115 is present in a small subset of basal and in most suprabasal, noncornified keratinocytes of the stratified epidermis, supporting epidermal transcriptomic data. In psoriatic skin, characterized by hyperproliferation and delayed differentiation, the expression of GPR115 and KRT1/10, the fundamental suprabasal keratin dimer, is delayed.