Publications by authors named "Rommel Mαrio Rodriguez Burbano"
Combined Therapy of ATRA and Imatinib Mesylate Decreases BCR-ABL and ABCB1/MDR1 Expression Through Cellular Differentiation in a Chronic Myeloid Leukemia Model.
Camila Albuquerque Pinto Adrhyann Jullyanne DE Sousa Portilho Maritza Cavalcante Barbosa Maria Elisabete Amaral DE Moraes José Alexandre Rodrigues DE Lemos Rommel Mαrio Rodriguez Burbano
In Vivo
August 2021
Background/aim: Chronic Myeloid Leukemia (CML) is a clonal myeloproliferative disease, and a major challenge for the eradication of CML is to understand the cause of the permanence of minimal residual disease (DRM). This work aimed to induce the maturation of leukemic stem cells with All-trans-retinoic acid (ATRA), making them sensitive to treatment with Imatinib (IM).
Materials And Methods: K562 cells were treated with IM and with the combined therapy of ATRA together with IM for 48 and 72 h.