Publications by authors named "Romina Waldner"
We performed a longitudinal shotgun metagenomic investigation of the plaque microbiome associated with peri-implant diseases in a cohort of 91 subjects with 320 quality-controlled metagenomes. Through recently improved taxonomic profiling methods, we identified the most discriminative species between healthy and diseased subjects at baseline, evaluated their change over time, and provided evidence that clinical treatment had a positive effect on plaque microbiome composition in patients affected by mucositis and peri-implantitis.
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- Dental implants are becoming more popular, but conditions like mucositis and peri-implantitis pose significant health and economic challenges due to microbial biofilms affecting the tissues around implants.
- A study using metagenomic sequencing of 113 samples from 72 individuals identified specific bacteria linked to these diseases, creating a "peri-implantitis-related complex" (PiRC) with seven key bacteria.
- The research found that the microbiome varies by site, with healthy areas resembling healthy implants, and highlighted Fusobacterium nucleatum as a crucial player in mucositis, demonstrating the potential of microbiome-based machine learning for diagnosing and understanding these conditions.