Publications by authors named "Romina Tortora"
Article Synopsis
- The study aimed to assess the safety and effectiveness of reirradiation (re-RT) using radiosurgery or fractionated stereotactic radiotherapy in combination with regorafenib for patients with recurrent glioblastoma (GBM).
- A total of 21 patients were observed, showing a median overall survival of 8.4 months and median progression-free survival of 6 months after treatment, with manageable side effects reported.
- The findings suggest that this treatment approach is safe, but further prospective trials are needed to establish standard protocols.
Purpose: For recurrent high-grade gliomas (HGG), no standard therapeutic approach has been reported; thus, surgery, chemotherapy, and re-irradiation (re-RT) may all be proposed. The aim of the study was to evaluate safety and efficacy of re-RT by radiosurgery or fractionated stereotactic radiotherapy (SRS/FSRT) in association to chemotherapy in patients with recurrent HGG.
Material/methods: All patients with histological diagnosis of HGG that suffered by recurrent disease diagnosed by magnetic resonance imaging (MRI), according to Response Assessment in Neuro-Oncology (RANO) criteria, after primary/adjuvant chemo-radiotherapy treatment and underwent to re-RT by SRS/FSRT were included in the analysis.