Publications by authors named "Romina Marcoccia"
Regenerative medicine applied to skin lesions is a field in constant improvement. The use of biomaterials with integrin agonists could promote cell adhesion increasing tissue repair processes. The aim of this pilot study was to analyze the effect of an α4β1 integrin agonist on cell adhesion of equine adipose tissue (AT) and Wharton's jelly (WJ) derived MSCs and to investigate their adhesion ability to GM18 incorporated poly L-lactic acid (PLLA) scaffolds.
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- Effective treatment guidelines exist for many canine diseases, but some dogs do not respond to standard care, leading owners to seek innovative therapies like mesenchymal stem cell (MSC) treatments.
- Researchers are exploring alternative sources for MSCs, such as fetal adnexa and fluid, due to their non-invasive, cost-effective, and ethically sound collection methods, as well as their unique properties.
- This review aims to provide an update on the use of MSCs from fetal sources in canine medicine, emphasizing recent clinical findings and their potential benefits.
Despite the increasing demand of cellular therapies for dogs, little is known on the differences between adult and fetal adnexa canine mesenchymal stem cells (MSCs), and data on their metabolic features are lacking. The present study aimed at comparing the characteristics of canine adipose tissue (AT) and umbilical cord matrix (UC) MSCs. Moreover, for the first time in the dog, the cellular bioenergetics were investigated by evaluating the two main metabolic pathways (oxidative phosphorylation and glycolysis) of ATP production.
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