Publications by authors named "Romina A Nand"
Treatment response to clopidogrel is associated with CYP2C19 activity through the formation of the active H4 metabolite. The aims of this study were to develop a physiologically based pharmacokinetic (PBPK) model of clopidogrel and its metabolites for populations of European ancestry, to predict the pharmacokinetics in the Japanese population by CYP2C19 phenotype, and to investigate the effect of clinical and demographic factors. A PBPK model was developed and verified to describe the two metabolic pathways of clopidogrel (H4 metabolite, acyl glucuronide metabolite) for a population of European ancestry using plasma data from published studies.
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- The study evaluated the pharmacokinetics and safety of a single 50-mg dose of pyrimethamine in healthy male subjects of Japanese and European ancestry, filling a gap in previous research on this medication.
- Results showed that pyrimethamine had a longer half-life in Japanese subjects (122.8 hours) compared to European subjects (99.5 hours), with slightly higher drug exposure for the Japanese group.
- No safety concerns emerged during the study, and despite the differences in exposure, the variation was deemed not significant compared to previous research on pyrimethamine.
Therapeutic drug monitoring of tacrolimus is complicated by the conflicting evidence of a relationship between trough blood tacrolimus concentration and clinical outcome. This prospective study investigated the blood distribution and protein binding of tacrolimus in liver transplant recipients over the first 60 days after transplantation with a view to identifying possible predictors of clinical outcome. Blood samples were collected from 10 liver transplant recipients on days 1, 7, and 60 after the initiation of tacrolimus therapy, and the distribution of tacrolimus in blood and the plasma protein binding were investigated.
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