Publications by authors named "Romi Pena"
Background: Environmental variance (V) is partly under genetic control and has recently been proposed as a measure of resilience. Unravelling the genetic background of the V of complex traits could help to improve resilience of livestock and stabilize their production across farming systems. The objective of this study was to identify genes and functional mutations associated with variation in V of litter size (LS) in rabbits.
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- The study aimed to identify genomic regions associated with intramuscular fat (IMF) content in two rabbit populations that have been selectively bred for this trait using a large genotyping dataset.
- Analysis revealed significant genomic regions on chromosomes OCU1, OCU8, and OCU13, with the highest variance explained found on OCU8 (7.34%), pointing to multiple potential candidate genes involved in fat metabolism and adipose cell function.
- Results suggest that the differences in IMF content are influenced by many genes, indicating a polygenic effect, and further research is needed to confirm these findings and assess their usefulness for breeding programs.
Uterine capacity (UC), defined as the total number of kits from unilaterally ovariectomized does at birth, has a high genetic correlation with litter size. The aim of our research was to identify genomic regions associated with litter size traits through a genomewide association study using rabbits from a divergent selection experiment for UC. A high-density SNP array (200K) was used to genotype 181 does from a control population, high and low UC lines.
View Article and Find Full Text PDFBackground: Recent studies in pigs have detected copy number variants (CNVs) using the Comparative Genomic Hybridization technique in arrays designed to cover specific porcine chromosomes. The goal of this study was to identify CNV regions (CNVRs) in swine species based on whole genome SNP genotyping chips.
Results: We used predictions from three different programs (cnvPartition, PennCNV and GADA) to analyze data from the Porcine SNP60 BeadChip.
Traditional methods of transgene delivery in livestock are inefficient. Recently, human immunodeficiency virus (HIV-1) based lentiviral vectors have been shown to offer an efficient transgene delivery system. We now extend this method by demonstrating efficient generation of transgenic pigs using an equine infectious anaemia virus derived vector.
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