Publications by authors named "Romeo Toko Feunaing"
3,3'4-trimethoxy-4'-rutinosylellagic acid and its acetylated derivative: Antioxidant activity and antiproliferative effects on breast cancer cells and molecular docking study.
Biomed Pharmacother
October 2024
Article Synopsis
- - The study investigates two natural compounds, TR2 and TR22, for their potential antioxidant and anticancer properties against two types of breast cancer cells (estrogen-sensitive MCF-7 and non-sensitive MDA-MB 231).
- - TR2 demonstrated stronger antioxidant effects compared to standard antioxidants and effectively inhibited the growth and migration of breast cancer cells, while TR22 showed a more significant proliferation inhibition following acetylation.
- - Molecular docking studies indicated that both compounds could inhibit receptor tyrosine kinases, suggesting their potential as effective agents in slowing cancer progression.
Article Synopsis
- Alzheimer's disease and diabetes impact global health, with specific enzymes targeted for treatment: acetylcholinesterase (AChE), butyrylcholinesterase (BChE) for AD, and α-amylase, α-glucosidase for diabetes.
- A study isolated various compounds from a medicinal plant, identifying several derivatives of ellagic acid that showed moderate to strong inhibition of AChE and BChE, with 3,3'-di-O-methyl ellagic acid being the most potent.
- In addition, some compounds effectively inhibited α-amylase and α-glucosidase, outperforming acarbose, indicating their potential as therapeutic agents for diabetes management.
The current study was conducted to isolate the phytoconstituents from leaves and stem bark and evaluate their inhibitory activity against α-glucosidase, digestive enzyme related to diabetes mellitus. Phytochemical investigation of the leaves resulted in the isolation of three saponins (3-5), two triterpenoids (7 and 8) and two steroids (10a and 10b) as inseparable mixture, while one saponin (6), one triterpenoid (9) and one mixture of two cinnamates (2a and 2b) were isolated from the stem bark. Except for compounds 2 b, 7, 8, 10a and 10 b all the isolated compounds are reported here for the first time from the genus .
View Article and Find Full Text PDFDiabetes mellitus is a metabolic disorder which is one of the leading causes of mortality and morbidities in elderly humans. Chronic diabetes can lead to kidney failure, blindness, limb amputation, heart attack and stroke. Physical activity, healthy diets and medications can reduce the incidence of diabetes, so the search for more efficient antidiabetic therapies, most especially from natural products, is a necessity.
View Article and Find Full Text PDFArticle Synopsis
- A new diterpenoid called rubesanolidic acid was discovered alongside six known compounds from the roots of a particular plant using column chromatography.
- Their structures were confirmed through various spectroscopic analyses and comparisons with prior research data.
- The extract showed significant -amylase inhibition activity, outperforming individual compounds, with rubesanolidic acid displaying the highest inhibition among the isolated compounds, suggesting the plant has potential as a source for antidiabetic agents.