Publications by authors named "Romeesa Khan"
Article Synopsis
- - Trillions of microbes in the gut significantly influence host immunity and metabolism through interactions in the microbiota-gut-brain axis (MGBA), affecting both neurological development and behavior!* - Changes in gut microbiota composition with aging have been linked to neurological diseases, with recent studies suggesting that targeting these microbes could improve behavioral health outcomes!* - The review discusses how gut and brain signaling pathways function, investigating how maternal microbiome aging impacts offspring and the role of the microbiome in chronic diseases like Parkinson's and Alzheimer's, as well as acute brain injuries.*
Microglia regulate anesthesia by altering the activity of neurons in specific regions of the brain via a purinergic receptor.
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- Stroke is a leading cause of long-term disability and poses a significant financial burden on global healthcare, with recovery largely influenced by ischemic injury and systemic inflammation.
- The study tested the effects of cromolyn, a mast cell stabilizer, on neuroinflammation and stroke outcomes using a mouse model, leading to reduced mast cell numbers in the brain and improved functional outcomes despite no significant differences in infarct volume.
- Results showed that cromolyn treatment decreased plasma histamine and IL-6 levels while also reducing gut mast cell numbers, suggesting that mast cell activity and trafficking are important factors in stroke recovery.
Background: Stroke is a major cause of morbidity and mortality, and its incidence increases with age. While acute therapies for stroke are currently limited to intravenous thrombolytics and endovascular thrombectomy, recent studies have implicated an important role for the gut microbiome in post-stroke neuroinflammation. After stroke, several immuno-regulatory pathways, including the aryl hydrocarbon receptor (AHR) pathway, become activated.
View Article and Find Full Text PDFLipofuscin is an autofluorescent (AF) pigment formed by lipids and misfolded proteins, which accumulates in postmitotic cells with advanced age. Here, we immunophenotyped microglia in the brain of old C57BL/6 mice (>18 months old) and demonstrate that in comparison to young mice, one-third of old microglia are AF, characterized by profound changes in lipid and iron content, phagocytic activity, and oxidative stress. Pharmacological depletion of microglia in old mice eliminated the AF microglia following repopulation and reversed microglial dysfunction.
View Article and Find Full Text PDFRecent studies have highlighted the deleterious contributions of B cells to post-stroke recovery and cognitive decline. Different B cell subsets have been proposed on the basis of expression levels of transcription factors (e.g.
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