Publications by authors named "Romani J"
There have been multiple studies on the use of Doppler ultrasound to define skin inflammation, but the visible vessels of healthy skin have yet to be described. This study aimed to evaluate the visible vessels of healthy skin using Doppler ultrasound. Prospective multicenter study using Doppler ultrasound to analyze healthy skin.
View Article and Find Full Text PDFIntroduction: Hidradenitis suppurativa (HS) is a skin disease which has a major impact on the patients' quality of life. There are still uncertainties surrounding its epidemiology, natural history and saftety and efficacy profile of existing treatments. The Spanish Academy of Dermatology and Venereology has promoted the creation of a Spanish Registry of patients with HS (REHS).
View Article and Find Full Text PDFInternational consensus statement on the use of ultrasound in hidradenitis suppurativa.
J Eur Acad Dermatol Venereol
February 2025
Background: So far, the evidence on the use of ultrasound (US) in hidradenitis suppurativa (HS) demonstrates the utility of US in the diagnosis, scoring and assessment of HS; however, to date, there is no international consensus statement on the use of US in HS, and several published guidelines do not include this topic.
Objectives: To create an international consensus statement on using US in HS that can cover and validate relevant aspects.
Methods: A three-round Delphi study with a panel of international experts representing four continents and working with US in HS in their daily practice.
Background: The reconstruction of surgical defects in high-tension anatomical regions is challenging due to the ischemia and subsequent necrosis associated with tension closure. Research on new flaps capable of closing these defects exerting less tension would be a tremendous advancement in dermatological surgery.
Patients And Methods: We conducted a multicenter, retrospective study that used 2 new flaps-the bishop and the sigma ones-to repair surgical defects in high-tension regions such as the scalp, lower extremities, and the nasal pyramid.
Real-world adalimumab survival and discontinuation factors in hidradenitis suppurativa.
J Eur Acad Dermatol Venereol
January 2025
Article Synopsis
- - The study analyzed the survival rate and interruption risks of adalimumab (ADA) treatment in 539 adult patients with hidradenitis suppurativa (HS), providing insights before and after the COVID-19 pandemic.
- - Findings revealed that about 39.92% of patients interrupted ADA, with the main reasons being inefficacy (51.69%) and adverse effects (21.35%); ADA showed a median overall drug survival of 56.2 months.
- - Factors like female gender, prolonged HS diagnosis, and higher HS severity correlated with decreased ADA survival, while post-pandemic trends included younger patients starting treatment at a lower HS stage.
Background: In 2013, Canoui-Poitrine et al. identified three hidradenitis suppurativa (HS) phenotypes by a latent class (LC) analysis, based on anatomical sites of involvement.
Objective: To improve the classification of the gluteal phenotype (LC3) patients given their diverse lesion types and differences in clinical profile.
Background: In 2013, Canoui-Poitrine et al. identified three hidradenitis suppurativa (HS) phenotypes by a latent class (LC) analysis, based on anatomical sites of involvement.
Objective: To improve the classification of the gluteal phenotype (LC3) patients given their diverse lesion types and differences in clinical profile.
Hidradenitis suppurativa is a chronic inflammatory disorder of the hair follicle with a high level of morbidity. Pilonidal sinus disease is a comorbid disorder and may be the reason for first contact with the healthcare system of patients with hidradenitis suppurativa. The aim of this study was to evaluate the frequency of association of pilonidal sinus disease and hidradenitis suppurativa and to explore whether pilonidal sinus disease defines a different clinical profile for patients with hidradenitis suppurativa.
View Article and Find Full Text PDFArticle Synopsis
- Hidradenitis suppurativa (HS) is a chronic skin condition characterized by painful lesions and involves high levels of interleukin-23; currently, adalimumab is the only approved treatment, while guselkumab's effectiveness for HS remains unclear.
- A multicenter retrospective study included 69 HS patients treated with guselkumab in Spain, focusing on safety and effectiveness through various health scores and patient-reported outcomes over 48 weeks.
- Results showed significant improvements in multiple clinical scores, with 58% of patients achieving clinical response by 24 weeks, though some discontinued due to inefficacy; no serious adverse events were reported.
Immune-Mediated Skin Reactions to Tumor Necrosis α Inhibitors: A Review of 30 Cases.
Actas Dermosifiliogr
January 2024
Article Synopsis
- TNF inhibitors, commonly used for treating inflammatory diseases, can cause unexpected skin reactions, with psoriasis being the most prevalent.* -
- A study examined 30 patients who developed skin issues like psoriasis, alopecia, or dermatitis while on TNF inhibitors, finding that 43.3% continued their treatment with significant improvement.* -
- Switching to biologics with different mechanisms was more successful in resolving symptoms, suggesting that treatment plans may not always need to change drastically for effective management of these reactions.*
Background: Braak's hypothesis states that sporadic Parkinson's disease (PD) follows a specific progression of pathology from the peripheral to the central nervous system, and this progression can be monitored by detecting the accumulation of alpha-Synuclein (α-Syn) protein. Consequently, there is growing interest in understanding how the gut (commensal) microbiome can regulate α-Syn accumulation, as this could potentially lead to PD.
Methods: We used 16S rRNA and shotgun sequencing to characterise microbial diversity.
Article Synopsis
- - The study evaluated the effectiveness and safety of guselkumab, a medication targeting IL-23, for treating moderate-severe hidradenitis suppurativa (HS), which is often challenging to manage.
- - Conducted in 13 hospitals in Spain, the study involved 69 patients, most of whom had severe HS and had previously tried multiple treatments, including adalimumab. Significant improvements in various clinical scores were noted after 48 weeks of guselkumab treatment.
- - About 58% of patients showed a clinical response within 16 weeks, and while some discontinued treatment mainly due to inefficacy, there were no serious side effects reported.
Background: Reconstruction of surgical defects located close to eyelid edges, nostrils, or the mouth is challenging, as tension generated by direct closure or skin flaps in these sensitive regions tends to cause distortion. New repair techniques that prevent retraction may significantly improve outcomes.
Patients And Methods: Retrospective study of the use of 2 novel flap designs-the nautilus flap and the bullfighter crutch flap-to repair surgical defects in the peripalpebral, perivestibular, nasal, and perioral areas.
Introduction: Since 2021, an increase in cases of tinea capitis has been detected in adolescents who shave their hair with fade haircut.
Patients And Methods: Multicenter retrospective observational study of cases of cephalic pole dermatophytosis with a history of having been acquired after frequent shaving in hairdressing. A call was made to dermatologists from the Spanish Academy of Dermatology and Venereology (AEDV) to provide cases observed between January 2021 and December 2022.
Article Synopsis
- A new parameter called IHS4-55, which indicates a 55% reduction in the severity of Hidradenitis Suppurativa (HS), was validated using data from patients treated with adalimumab and placebo.
- The research aimed to externally validate the IHS4-55 in patients treated with antibiotics, assessing its correlation with the reduction of inflammatory lesions and quality of life metrics.
- Results from a study of 283 patients showed that those achieving IHS4-55 experienced significant reductions in inflammatory nodules and had a greater likelihood of improving quality of life scores, supporting its use as a key outcome measure in clinical trials.
Background: Pain is not a trivial issue for hidradenitis suppurativa (HS) patients and has been considered a domain in the Core Outcome Set. To date, there is no evidence about pain caused by the ultrasound examinations.
Objective: The aim of the study was to assess the presence of pain generated by the ultrasound examinations of HS patients.
Objectives: Calcium depositions are frequent in multiple inflammatory dermatosis, they can be explored by ultrasound (US) but the patterns of these depositions have not yet been described. The aim of this study is to describe different patterns of calcium deposition in inflammatory dermatoses.
Methods: The clinical and US data of 58 patients from 7 different centers with inflammatory dermatosis showing ultrasonography-detected calcium depositions was retrospectively reviewed.