Adjunctive use of omega-3 fatty acids in combination with low-dose aspirin in periodontitis: Systematic review and meta-analysis.

Periodontitis is one of the most common dental diseases with a range of treatment approaches, including pathogenetically reasonable use of various host immune modulators. One such approach is the use of omega-3 polyunsaturated fatty acids (PUFAs) in combination with low-dose aspirin. This systematic review and meta-analysis were performed to compare the standard treatment alone and adjunctive use of omega-3 PUFAs in combination with low-dose aspirin with or without standard treatment in patients with periodontitis.

On-Demand Cell Sheet Release with Low Density Peptide-Functionalized Non-LCST Polymer Brushes.

Cell sheet harvesting offers a great potential for the development of new therapies for regenerative medicine. For cells to adhere onto surfaces, proliferate, and to be released on demand, thermoresponsive polymeric coatings are generally considered to be required. Herein, an alternative approach for the cell sheet harvesting and rapid release on demand is reported, circumventing the use of thermoresponsive materials.

Bone Remodeling Interaction with Magnesium Alloy Implants Studied by SEM and EDX.

The development direction of bioresorbable fixing structures is currently very relevant because it corresponds to the priority areas in worldwide biotechnology development. Magnesium (Mg)-based alloys are gaining high levels of attention due to their promising potential use as the basis for fixating structures. These alloys can be an alternative to non-degradable metal implants in orthopedics, maxillofacial surgery, neurosurgery, and veterinary medicine.

Potentiometric Performance of Ion-Selective Electrodes Based on Polyaniline and Chelating Agents: Detection of Fe or Fe Ions.

We constructed a sensor for the determination of Fe and/or Fe ions that consists of a polyaniline layer as an ion-to-electron transducer; on top of it, chelating molecules are deposited (which can selectively chelate specific ions) and protected with a non-biofouling poly(2-methyl-2-oxazoline)s layer. We have shown that our potentiometric sensing layers show a rapid response to the presence of Fe or Fe ions, do not experience interference with other ions (such as Cu), and work in a biological environment in the presence of bovine serum albumin (as a model serum protein). The sensing layers detect iron ions in the concentration range from 5 nM to 50 µM.

Conformation in Ultrathin Polymer Brush Coatings Resolved by Infrared Nanoscopy.

Polymer brush coatings are effective in preventing blood coagulation or bacterial attachment, but their chain conformation, while vital for this effect, was never characterized in high spatial resolution. Here, we report mid-infrared spectroscopic nanoscopy studies of few-nanometer-thin poly(ethylene oxide) (PEO) films which reveal marked spectral variations along the surface at a length scale smaller than 100 nm and originating only from the physical conformation of the chains. The conformation and average orientation of the polymer chains in the layer is extracted from the spectra with the aid of theoretic modeling, confirming the spontaneous formation of a crystalline phase.

[The need of children of the Crimean regions with different medical and social conditions in orthodontic treatment].

The aim of the study was to investigate the needs of children of various Crimean regions in orthodontic care. The epidemiological survey involved 125 children under the age of 12 years old living in the regions of Crimea with different levels of medical and social conditions (Alushta, Simferopol, Lenin and the Krasnogvardeisky district). The two-component IOTN index was used in investigation.

Knowledge Transfer Between Artificial Intelligence Systems.

We consider the fundamental question: how a legacy "student" Artificial Intelligent (AI) system could learn from a legacy "teacher" AI system or a human expert without re-training and, most importantly, without requiring significant computational resources. Here "learning" is broadly understood as an ability of one system to mimic responses of the other to an incoming stimulation and vice-versa. We call such learning an Artificial Intelligence knowledge transfer.

[Urgent cardiovascular conditions in dental practice].

Cardiovascular diseases rank first in disease patterns and their prevalence increases in most countrie, including Russian Federation. The paper presents guidelines for approaches prevention of urgent cardiovascular conditions and measures to provide first medical aid which will help avoid the negative effects in the acute clinical situations.

A Solid Iridium Catalyst for Diastereoselective Hydrogenation.

An Ir(NHC) supported catalyst is used in the selective hydrogenation of terpinen-4-ol to cis p-menthan-4-ol. Its activity, selectivity and stability are compared to those of a homogeneous homologue [IrCl(COD)MesImPr] and to a commercial Pd/C. The solid Ir catalyst is much more selective than the Pd catalyst (92 vs.

Iridium(I)/N-Heterocyclic Carbene Hybrid Materials: Surface Stabilization of Low-Valent Iridium Species for High Catalytic Hydrogenation Performance.

An Ir(I) (NHC)-based hybrid material was prepared using a methodology which allowed the precise positioning and isolation of the Ir centers along the pore channels of a silica framework. The full characterization of the material by solid-state NMR spectroscopy showed that the supported Ir sites were stabilized by the silica surface, as low-coordinated single-site complexes. The material is extremely efficient for the hydrogenation of functional alkenes.

[Effectiveness of medical rehabilitation of women of reproductive age with fatigue syndrome].

Efficacy Erbisol in combination with Lymphomyosot and Echinacea compositum C in medical rehabilitation of women of reproductive age with fatigue syndrome and chronic gynecological pathology was studied. It was found that this complex of medications promotes faster and more effective reduction of the level of circulating immune complexes in the serum, achievement of persistent clinical remission of disease and liquidation of fatigue syndrome manifestations, what improves the quality of life of patients.

[Possible effect of E-selectine on structure and function of arterial vessels in patients with metabolic syndrome].

Endothelial dysfunction and endothelial cells activation as it was shown in patients with ischemic heart disease play important role in atherosclerosis progression and the development of cardiovascular events. Relationship between E-selectine and functional/ structural changes of the arterial vessels in patients with metabolic syndrome was not explored. We revealed that both activation of the endothelial cells and structural/functional changes of the arterial wall mostly depend on obesity and dislipedemia and in less extent on carbohydrates metabolism disorders.

[Outpatient diagnosis of oxidant stress in patients with carbohydrate metabolism disturbance in metabolic syndrome].

Aim: To compare lipid peroxidation (LPO), (NO)-endothelium system in disorders of glucose tolerance (DGT) in patients with metabolic syndrome (MS) and diabetes mellitus type 2 (DM2).

Material And Methods: The trial included 178 patients with DGT and DM2 within MS (WHO, 1999). The control group consisted of 40 healthy subjects free of MS.

[Diagnostics of disorders in lipid and carbohydrate metabolism in women with hypertension in outpatient clinic].

Aim: To study lipid and carbohydrate metabolism in young and middle-aged women with essential hypertension (EH).

Material And Methods: Anthropometric parameters, arterial pressure (AP), glucose tolerance (GT), fasting glucose, immunoreactive insulin (IRI), glycosylated hemoglobin (HbA1), total cholesterol (TC), triglycerides (TG), HDLP cholesterol, atherogenic index were estimated in 93 women aged 20 to 50 years with EH stage II.

Results: TC was elevated in 75%, HDLP cholesterol--in 52%, TG--in 40% patients.

[Psychoautonomic disorders in painful vertebrogenic syndromes].

Compression spectral analysis of EEG and electropolygraphic registration (EMG, SGR, ECG), psychological and clinical investigations were used to examine patients with right and left vertebrogenic pain syndrome, patients with psychogenic neurotic syndrome and control group of healthy subjects. It was found that vertebrogenic syndrome frequently combined with psychogenic disorders. The latter were more evident in the left-side syndromes, occurred in more severe EEG abnormality.

[The effect of ultrasound, the polyene antibiotic amphotericin B and their combination on the biomembranes of yeast-like fungi in the genus Candida].

The effect of ultrasound (US) and the antibiotic amphotericin (A-B) on the structure of Candida albicans membranes. The most expression of destructive processes and appearance of free radicals in mycetic cells was observed in combination of US and A-B by chemiluminescence and ultrastructural analyses. The mechanisms of action of US and A-B on mycetic cells were discussed in the article.

[The cellular acid phosphatase activity in yeast-like fungi of the genus Candida exposed to ultrasound, polyene antibiotics and dyes].

The activity of one of the lysosomal membrane marker enzymes--acid phosphatase from the Candida yeast fungi on their exposure to ultrasound (US), polyenic antibiotics (amphotericin B and nystatin) dye antiseptics (ethacridine lactate, methylene blue), and their combinations was assayed. The impact of US and the drugs, in particular their combination, was found to be followed by activation of the fungal lysosomal apparatus function and increases in their catabolic processes. The highest rise in lysosomal catabolic activity was found when the polyenic antibiotics were used in combination with US, which reflects the higher damaging effect of this combination against Candida lysosomal membranes than the dyes and of these antibiotics and US alone.

[The characteristics of the ultrastructural changes in yeast-like fungi of the genus Candida exposed to therapeutic-range ultrasound and nystatin].

The electron microscopic study of the ultrastructure of yeast-like fungi of the genus Candida under the action of nystatin and sonication, as well as the action of these two factors used in combination, was carried out. In this study the degree of preservation of the structure of fungal cells was evaluated and the percentage of cells with different ultrastructural changes was determined. Observations made 3 and 24 hours after sonication and treatment with nystatin, used in combination, showed that ultrastructural changes in fungal cells were more pronounced than in the cells subjected to the action of nystatin alone.

[A comparative evaluation of amphotericin pharmacokinetics in the skin and subcutaneous fatty tissue when used dermally and by phonophoresis].

During the combined use of the ointment with amphotericin B and ultrasound after 1, 3, 24, 48 and 72 hours there was detected a higher content of the drug in the skin and the subcutaneous fatty tissue as compared with the epicutaneous application of the ointment without ultrasound. The drug contents in the insonified and non-insonified samples increased by the 3rd hour after the application except the insonified skin, where the maximal values were noted after 1 hour; subsequently (after 24, 48 and 72 hours) amphotericin B concentration gradually decreased. It remained significantly higher in the insonified samples than in the non-insonified ones.

[Comparative levels of amphotericin B in the skin and subcutaneous fatty tissue after cutaneous application of amphotericin ointment by phonophoresis and with preliminary treatment by dimethyl sulfoxide].

A comparative study of the amphotericin B contents in the skin and subcutaneous fatty tissue was performed on guinea pigs after local application of amphotericin ointment by phonophoresis and with preliminary treatment of the skin by dimethyl sulfoxide (DMSO). When the amphotericin ointment was used in combination with ultrasound the content of amphotericin B in the skin and subcutaneous fatty tissue 1, 3, 24, 48 and 72 hours after the application was much higher than that after the ointment local application without the ultrasonic treatment. When the amphotericin ointment was applied locally after the preliminary treatment with DMSO the maximum content of the antibiotic in the skin and subcutaneous fatty tissue was observed 3 hours after the application which was significantly higher than the content observed after the ointment application by phonophoresis and especially locally without the ultrasonic treatment.

[The effect of ultrasonic oscillations and amphotericin B on the ultrastructure of yeast-like fungi in the genus Candida].

C. albicans cellular structure was examined electron microscopically over the course of amphotericin B treatment. The efficacy of amphotericin B administration via phonophoresis is demonstrated.