Neurotensin and Its Involvement in Female Hormone-Sensitive Cancers.

Neurotensin (NT) is a peptide involved in digestion, neuromodulation, and cancer progression. NT and its receptors (NTR1 and SORT1 mainly) have been widely studied in oncology. Data show that NT expression is under the control of sex steroid hormones, in particular estradiol.

[Fertility counseling: a new care to be developed in France].

Objective: The abandonment of the criterion of pathological infertility in ART and the societal preservation of fertility (FP) are the founders of a new practice which puts the parental project at the center of the support. It is in this context that the University Hospital of Nancy fertility Center has created fertility counselling (FC) care, allowing anyone single or in a couple who wishes to learn about their fertility access to fertility specialists in order to be informed by professionals of the medical, biological and regulatory possibilities of access to parenthood.

Methods: We conducted a single-center retrospective observational study from January 1, 2020, to April 30, 2023, in the Nancy Fertility Center.

Expressions of HuR, Methyl-HuR and Phospho-HuR in Endometrial Endometrioid Adenocarcinoma Are Associated with Clinical Features.

HuR regulates cytoplasmic mRNA stability and translatability, with its expression correlating with adverse outcomes in various cancers. This study aimed to assess the prognostic value and pro-oncogenic properties of HuR and its post-translational isoforms methyl-HuR and phospho-HuR in endometrial adenocarcinoma. Examining 89 endometrioid adenocarcinomas, we analyzed the relationship between HuR nuclear or cytoplasmic immunostaining, tumor-cell proliferation, and patient survival.

Assisted reproductive technology in France: The reproductive rights of LGBT people.

Background: In 2021, France authorized ART with sperm donor for female couples and single women.

Objectives: We summarize here the possibilities of ART among LGBT people in France to date, pointing out the main restrictions for LGBT reproductive rights, requiring future legislative changes.

Results: Despite the latest modification of the French bioethics laws which notably opens ART to female couples, French legislation still excludes most LGBT people from parenthood through ART, especially gay men and transgender people in most cases.

Neurotensin and Its Involvement in Reproductive Functions: An Exhaustive Review of the Literature.

Neurotensin (NTS) is a peptide discovered in 1973, which has been studied in many fields and mainly in oncology for its action in tumor growth and proliferation. In this review of the literature, we wanted to focus on its involvement in reproductive functions. NTS participates in an autocrine manner in the mechanisms of ovulation via NTS receptor 3 (NTSR3), present in granulosa cells.