Methadone versus buprenorphine in pregnant addicts: a double-blind, double-dummy comparison study.

Aims: To evaluate the efficacy and safety of methadone versus buprenorphine treatment in pregnant opioid-dependent women.

Design: Randomized, double-dummy, double-blind, flexible-dosing comparison study.

Setting: Addiction Clinic at the Medical University of Vienna, Austria.

Use of slow-release oral morphine for the treatment of opioid dependence.

Aims: In addition to methadone, other synthetic opioids are now available for the treatment of opioid dependence. The study investigated the treatment satisfaction of oral slow-release morphine for maintenance therapy in opioid-dependent patients in an open-label 3-week study.

Design: We evaluated the treatment satisfaction of oral slow-release morphine hydrochloride for 3 weeks in 110 patients meeting the diagnosis of opioid dependence (DSM-IV 304.

Buprenorphine maintenance: office-based treatment with addiction clinic support.

Introduction: Buprenorphine has already been registered in 27 European countries for maintenance therapy in opioid-dependent patients. In our office-based prescription study we applied sublingual buprenorphine, initiating the treatment at the addiction clinic with subsequent treatment at the offices of general practitioners (GPs) to evaluate its efficacy and feasibility in two different treatment settings.

Methods: Sixty opioid-dependent patients were studied for a period of 15 weeks.

Maintenance therapy with synthetic opioids and driving aptitude.

Aims: To assess the influence of methadone and buprenorphine maintenance treatment on the driving aptitude of opioid-dependent patients.

Design: Prospective, open label, outpatient maintenance, single-blind (investigator) study.

Participants And Setting: Thirty opioid-dependent patients maintained on either methadone or buprenorphine were recruited from the drug-addiction outpatient clinic in Vienna.

[Slow-release morphine hydrochloride for maintenance therapy of opioid dependence].

Introduction: In Austria, methadone, buprenorphine as well as oral slow-release morphine are used for the treatment of opioid dependence. This controlled examination marks the first time that oral slow-release morphine hydrochloride is applied for maintenance therapy in opioid dependent subjects.

Methods: In order to evaluate the effectiveness of this psychopharmacological medication, we examined patients over a three-week period.

Neonatal outcome following buprenorphine maintenance during conception and throughout pregnancy.

Aims: To assess the effects of maternal buprenorphine treatment at conception and during pregnancy on neonates in terms of birth outcomes and neonatal abstinence syndrome (NAS).

Design And Setting: Prospective, open-label, out-patient maintenance, case report study, conducted at the drug addiction out-patient clinic at the University Hospital Vienna.

Participants: Two buprenorphine-maintained pregnant women who had conceived during buprenorphine treatment.