How can the failure mode and effect analysis improve the working processes in the ART center?

Objective(s): Assisted reproductive technology (ART) Centers and laboratories perform complex tasks with patients and their gametes/embryos daily. The degree of problems/non-conformances in such surroundings must be minimized at zero point. This study aimed to establish the proper risk management system with well-defined process steps to prevent and eliminate problems/non-conformances.

Chromosomal segregation in sperm of the Robertsonian translocation (21;22) carrier and its impact on IVF outcome.

Purpose: To assess the variability of meiotic segregation patterns in sperm of Robertsonian translocation (RobT) carrier t(21;22) and present effect on reproductive outcome.

Methods: Infertile couple enrolled in IVF/ICSI program. Sperm chromosomal segregation analysis was done using FISH; preimplantation genetic testing for aneuploids (PGT-A) was performed by NGS.

Continuous compared with cyclic oral contraceptives for the treatment of primary dysmenorrhea: a randomized controlled trial.

Objective: To estimate whether continuous oral contraceptive pills (OCPs) will result in more pain relief in primary dysmenorrhea patients than cyclic OCPs, which induce withdrawal bleeding with associated pain and symptoms.

Methods: We conducted a double-blind, randomized, controlled trial comparing continuous to a cyclic 21-7 OCP regimen (gestodene 0.075 mg and ethinyl estradiol 20 microgram) for 6 months in 38 primary dysmenorrhea patients.

Continuous glucose monitoring during pregnancy in women with polycystic ovary syndrome.

Objective: To estimate whether women with polycystic ovary syndrome (PCOS) will display ambient hyperglycemia (as measured by continuous glucose monitoring) early in pregnancy that progressively exacerbates with advancing pregnancy.

Methods: This was a case-control study during singleton pregnancies of 17 women with PCOS and 17 healthy women. A 75-g oral glucose tolerance test (OGTT) followed by 24-hour continuous glucose monitoring was obtained four times throughout the pregnancy (visit 1: 6-10 weeks; visit 2: 12-16 weeks; visit 3: 24-28 weeks; visit 4: 34-38 weeks).

Endometrial growth in early pregnancy after IVF/ET.

Purpose: To detect the endometrial volume change in conception cycles. Additionally we measured endometrium in three planes, to see if the hypothesized endometrial volume differences will be detectable by this surrogate technique.

Methods: Following the embryo transfer, a three-dimensional ultrasound exam was performed on average days 22 and 28 of the cycle.

Should the practice of double blastocyst transfer be abandoned? A retrospective analysis.

As multiple pregnancy is now considered to be an adverse event of an IVF procedure, reducing the multiple pregnancy rates has become the goal of many IVF centres. A large number of double blastocyst transfers in non-selected patients were performed in the author's institution over recent years, and a retrospective analysis was conducted to investigate if multiple pregnancy rates in such a population are still unacceptably high. In addition, the factors determining the birth of singletons or multiple births following the transfer of two blastocysts was analysed.

Comparison of hormonal and metabolic markers after a high-fat, Western meal versus a low-fat, high-fiber meal in women with polycystic ovary syndrome.

Objective: To determine the effect of meal composition on postprandial T levels in women with polycystic ovary syndrome (PCOS).

Design: Randomized, crossover design.

Setting: Academic research center.

Pericentric inversion of chromosome 2 in a patient with the empty follicle syndrome: case report.

The empty follicle syndrome (EFS) is defined as a lack of retrieved oocytes from follicles, at the time of repeated aspiration and flushing, following ovulation induction. The actual mechanism responsible for the EFS is still unknown. The aim of this study was to offer more information regarding the possible connection of this syndrome with pericentric inversion of chromosome 2.

Long-term treatment with vaginal estradiol tablets--an impact on uterine artery blood flow.

Objective: We investigated, using color Doppler ultrasound, possible detectable blood changes of prolonged treatment with 17-beta-estradiol tablets on uterine artery blood flow, in a cohort of low risk postmenopausal women.

Methods: 39 postmenopausal women, who were taking local estrogen therapy for at least 6 months, were examined in the study group. Forty-two women who never used hormone replacement therapy consisted a control group.

Ultrasound-estimated bladder weight in healthy children.

Bladder weight in healthy children was determined ultrasonographically using a modified formula that takes into account the different shapes of the urinary bladder. Ultrasonographic examination of the bladder was performed on 92 healthy children (56 boys, 36 girls) with a 5-MHz transducer. Bladders were categorized into five groups according to shape, and three bladder diameters were measured.

Severity of symptoms in primary dysmenorrhea--a Doppler study.

Objective: Doppler findings in women with severe symptoms of primary dysmenorrhea include high impedance to blood flow in uterine arteries with a preserved cyclic pattern throughout the whole cycle. Doppler findings in women who present with mild symptoms of primary dysmenorrhea are not yet documented. The aim of this study was to investigate possible differences in Doppler findings among women with mild and severe primary dysmenorrhea.

Doppler sonographic renal resistance index and resistance index ratio in children and adolescents with unilateral hydronephrosis.

The aim of this study was to evaluate Doppler renal resistance index (RI) and RI ratio (RIR) in differentiating between obstructive and nonobstructive hydronephrosis in children and adolescents. The RI and RIR were measured in 32 healthy examinees (control group) and 29 patients with unilateral hydronephrosis. Ten patients had acute obstruction caused by a ureteric stone.