Publications by authors named "Roman Y Lutkovskiy"
In this study, we investigated the features of co-infection with SARS-CoV-2 and the enterovirus vaccine strain LEV8 of coxsackievirus A7 or enterovirus A71 for Vero E6 cells and Syrian hamsters. The investigation of co-infection with SARS-CoV-2 and LEV-8 or EV-A71 in the cell model showed that a competitive inhibitory effect for these viruses was especially significant against SARS-CoV-2. Pre-infection with enteroviruses in the animals caused more than a 100-fold decrease in the levels of SARS-CoV-2 virus replication in the respiratory tract and more rapid clearance of infectious SARS-CoV-2 from the lower respiratory tract.
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- The study analyzed the effects of co-infection with SARS-CoV-2 and other viruses (HAdV-5 or IAV) in lab settings, both in vitro and in vivo.
- During co-infection, HAdV-5 did not hinder the replication of SARS-CoV-2, showing similar viral levels in lungs of infected hamsters.
- Co-infected animals showed more severe illness and lung damage compared to those infected with SARS-CoV-2 alone, indicating that mixed infections can lead to heightened disease severity.