Malaysia outbreak survivors retain detectable Nipah antibodies and memory B cells after 25 years.

Objective: To evaluate the long-term humoral immune response to Nipah virus (NiV) in a cohort of 25 survivors after 25 years of post-infection.

Methods: A total of 25 survivors of NiV infection from the 1998 outbreak were recruited for sample collection. The serum IgG antibody response to NiV antigens, specifically nucleocapsid (N), fusion glycoprotein (F) and attachment glycoprotein (G) was evaluated using ELISA.

CAECENET: An automatic system processing photometer and ceilometer data from different networks to provide columnar and vertically-resolved aerosol properties.

This work introduces CAECENET, a new system capable of automatically retrieving columnar and vertically-resolved aerosol properties running the GRASP (Generalized Retrieval of Atmosphere and Surface Properties) algorithm using sun-sky photometer (aerosol optical depth, AOD; and sky radiance measurements) and ceilometer (range corrected signal; RCS) data as input. This method, so called GRASPpac, is implemented in CAECENET, which assimilates sun-sky photometers data from CÆLIS database and ceilometer data from ICENET database (Iberian Ceilometer Network). CAECENET allows for continuous and near-real-time monitoring of both vertical and columnar aerosol properties.

Defining quality categories for evaluation of the doctor-patient relationship assessed through the patient-doctor relationship questionnaire (PDRQ-9).

Background: The quality of the doctor-patient relationship plays a crucial role in patients' experiences with healthcare services, positively influencing clinical outcomes and satisfaction with care. The Patient-Doctor Relationship Questionnaire (PDRQ-9) is widely used to assess this relationship. However, there are no quality categories that can be derived from the instrument's score to facilitate understanding and decision-making.

Collaborative Outcomes Study on Health and Functioning During Infection Times (COH-FIT): Global and Risk-Group Stratified Course of Well-Being and Mental Health During the COVID-19 Pandemic in Adolescents.

Objective: To identify the COVID-19 pandemic impact on well-being/mental health, coping strategies, and risk factors in adolescents worldwide.

Method: This study was based on an anonymous online multi-national/multi-language survey in the general population (representative/weighted non-representative samples, 14-17 years of age), measuring change in well-being (World Health Organization-Five Well-Being Index [WHO-5]/range = 0-100) and psychopathology (validated composite P-score/range = 0-100), WHO-5 <50 and <29, pre- vs during COVID-19 pandemic (April 26, 2020-June 26, 2022). Coping strategies and 9 a priori- defined individual/cumulative risk factors were measured.

Uncertainty-Aware Deep Learning Characterization of Knee Radiographs for Large-Scale Registry Creation.

Background: We present an automated image ingestion pipeline for a knee radiography registry, integrating a multilabel image-semantic classifier with conformal prediction-based uncertainty quantification and an object detection model for knee hardware.

Methods: Annotators retrospectively classified 26,000 knee images detailing presence, laterality, prostheses, and radiographic views. They further annotated surgical construct locations in 11,841 knee radiographs.

Optimizing survival and growth of inoculated biocrust-forming cyanobacteria through native plant-based habitat amelioration.

Low restoration success in degraded drylands has promoted research efforts towards recovery of pioneer components of these ecosystems such as biocrusts. Biocrusts can stabilize soils and improve nutrient cycling to assist vegetation establishment, but their natural recovery following a disturbance may be very slow. Soil inoculation with biocrust-forming components such as cyanobacteria is widely spread to foster biocrust formation.

An Examination of Temporomandibular Joint Disc Displacement through Magnetic Resonance Imaging by Integrating Artificial Intelligence: Preliminary Findings.

This research was aimed at constructing a complete automated temporomandibular joint disc position identification system that could assist with magnetic resonance imaging disc displacement diagnosis on oblique sagittal and oblique coronal images. The study included fifty subjects with magnetic resonance imaging scans of the temporomandibular joint. Oblique sagittal and coronal sections of the magnetic resonance imaging scans were analyzed.

The Impact of Leg Length and Offset Change on Dislocation Risk Following Primary Total Hip Arthroplasty.

Background: Soft tissue management in total hip arthroplasty includes appropriate restoration and/or alteration of leg length (LL) and offset to re-establish natural hip biomechanics. The purpose of this study was to evaluate the effect of LL and offset-derived variables in a multivariable survival model for dislocation.

Methods: Clinical, surgical, and radiographic data was retrospectively acquired for 12,582 patients undergoing primary total hip arthroplasty at a single institution from 1998 to 2018.

Inhibition of Soluble Epoxide Hydrolase Ameliorates Cerebral Blood Flow Autoregulation and Cognition in Alzheimer's Disease and Diabetes-Related Dementia Rat Models.

Alzheimer's Disease and Alzheimer's Disease-related dementias (AD/ADRD) pose major global healthcare challenges, with diabetes mellitus (DM) being a key risk factor. Both AD and DM-related ADRD are characterized by reduced cerebral blood flow, although the exact mechanisms remain unclear. We previously identified compromised cerebral hemodynamics as early signs in TgF344-AD and type 2 DM-ADRD (T2DN) rat models.

20-HETE and Hypertension.

Previous studies established that arachidonic acid is metabolized by the cytochrome P450 (CYP) enzymes of the 4A and 4F families to 20-hydroxyeicosatetraenoic (20-HETE) that regulates renal function and vascular tone. Elevations in the 20-HETE have been reported to increase blood pressure by promoting endothelial dysfunction, vascular inflammation, oxidative stress and endothelial expression of angiotensin-converting enzyme, which increase circulating angiotensin II levels. However, mutations in and that inhibit the formation of 20-HETE have been linked to hypertension in human genetic studies, and a deficiency in 20-HETE promotes sodium retention and hypertension in Dahl salt-sensitive rats.

Developing Knowledge of Autism in Majority World Countries: Examples of Bolivia and Paraguay.

Bolivia and Paraguay are Majority World countries, which are defined as areas within which most of the world's population live, natural resources and landmass are located, but are often economically poor. Minority world countries, such as, the United States, have a smaller percentage of the world's population, but often a greater share of the world's wealth. Many Majority World countries, such as Bolivia and Paraguay, have not collected prevalence data on autism and assessments and interventions for persons are quite limited, if they are available at all.

Star-Like Polypeptides as Simplified Analogues of Horseradish Peroxidase (HRP) Metalloenzymes.

Peroxidases, like horseradish peroxidase (HRP), are heme metalloenzymes that are powerful biocatalysts for various oxidation reactions. By using simple grafting-from approach, ring-opening polymerization (ROP), and manganese porphyrins, star-shaped polypeptides analogues of HRP capable of catalyzing oxidation reactions with HO is successfully prepared. Like their protein model, these simplified analogues show interesting Michaelis-Menten constant (K) in the mM range for the oxidant.

Native Biocrust Cyanobacteria Strains Showing Antagonism against Three Soilborne Pathogenic Fungi.

The biocontrol potential of three native soil cyanobacteria from biological soil crusts (, , and ) was tested by means of in vitro mycelial growth inhibition assays for eighteen cyanobacteria-based products against three phytopathogenic soilborne fungi (, , and f. sp. ).

Impact of the COVID-19 Pandemic on the Surgical Management of Head and Neck Non-Melanoma Skin Cancers in a Maxillofacial Center of Cluj-Napoca.

: The COVID-19 era has been a bleak period for both cancer and non-cancer patients, with delayed non-emergency treatments, such as for non-melanoma skin cancer (NMSC). This study aimed to evaluate how the treatment of NMSC patients was influenced by the management of the COVID-19 pandemic in an Eastern European Maxillofacial Surgery center. : A total of 176 patients with a histopathological diagnosis of head and neck NMSC who were surgically treated in Cluj-Napoca Emergency County Hospital between 2016 and 2022 were included in this study, and divided into two samples, pre-pandemic (2016-2019) and COVID-19 (2020-2022) periods.

Platelet-Rich Fibrin Treatment Evaluation in Patients with Medication-Related Osteonecrosis of the Jaw and Osteoradionecrosis.

Medication-related osteonecrosis of the jaw (MRONJ) and osteoradionecrosis (ORN) are associated with severe disability and continuous pain, both of which are very difficult to control. This study aims to evaluate the outcome of platelet-rich fibrin (PRF) treatment compared to iodoform gauze packing and the primary suture of oral mucosa in patients with both MRONJ and ORN. Patients suffering from MRONJ and ORN who were treated in the Oral and Maxillofacial Surgery Clinic of Cluj-Napoca in the last 10 years were selected for this study from the hospital database.

Ultrasound Evaluation of Uterine Cavity Changes After Stimulation for In Vitro Fertilization.

Objectives: Mock embryo transfer (ET) before in vitro fertilization (IVF) allows for the clinical determination of uterine cavity length (UCL) to optimize embryo placement during clinical ET. Most studies have shown that optimal pregnancy rates occur with clinical ET at a depth of 15 mm from the uterine fundus. In our study, we sought to determine the effect of ovarian stimulation and endometrial preparation on UCL using 2D transabdominal ultrasound.